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. 1982 Jul;151(1):510–515. doi: 10.1128/jb.151.1.510-515.1982

Utilization by Saccharomyces cerevisiae of 5'-methylthioadenosine as a source of both purine and methionine.

M C Cone, K Marchitto, B Zehfus, A J Ferro
PMCID: PMC220274  PMID: 7045086

Abstract

Cells of the yeast Saccharomyces cerevisiae are normally impermeable to the purine nucleosides adenosine and 5'-deoxy-5'-methylthioadenosine (MTA), a product of polyamine biosynthesis. cordycepin-sensitive, adenosine-utilizing strains of S. cerevisiae were able to use MTA to fulfill an auxotrophic requirement for purine. Cordycepin-sensitive strains carrying a met5 mutation were also able to use MTA as a source of methionine. These MTA-utilizing strains of S. cerevisiae should be useful for metabolic studies of the fate of MTA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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