Abstract
45Ca efflux was studied in resting anterior byssal retractor muscle. The data are described by a three-compartment system. The most rapidly exchanging compartment, with an average time constant of 7 min, contains about 0.9 mM Ca/liter muscle, and probably represents extracellular space. A second compartment, with a time constant of 83 ± 5 min, contains 1.2 mM Ca/liter, and may represent a membrane calcium store. The presence of a third, or more, compartments, probably representing sarcoplasmic reticulum and contractile proteins, is indicated by the fact that the final time constant is 10 times the 83 min time constant of the second compartment. Serotonin (5HT), on initial application, increases 45Ca efflux from this third compartment(s). This effect has a typical dose-response relationship with a maximum response appearing at 10-7 M5HT. In addition, removal of 5HT causes a secondary increase in 45Ca efflux which has a maximum at a 5HT concentration of 10-7 M and declines at both higher and lower doses.
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Selected References
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