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. 1974 Jan 1;63(1):62–87. doi: 10.1085/jgp.63.1.62

Control of Retinal Sensitivity

II. Lateral Interactions at the Outer Plexiform Layer

Frank S Werblin 1
PMCID: PMC2203539  PMID: 4359064

Abstract

Test stimuli, presented at the center of the bipolar cell receptive field, spanning less than 2 log units of intensity, elicit the full range of graded response. The intensity range of test stimuli that elicits the graded response depends upon the background conditions. A higher range of log test intensities is required to elicit the graded bipolar response in the presence of surround backgrounds. But surround backgrounds can also serve to unsaturate the bipolar response and thereby increase sensitivity under certain conditions. The results suggest that a second stage of sensitivity-control is mediated by the horizontal cell system at the outer plexiform layer, concatenated with the effects of adaptation in the photoreceptors.

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Selected References

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  1. Baylor D. A., Fuortes M. G., O'Bryan P. M. Receptive fields of cones in the retina of the turtle. J Physiol. 1971 Apr;214(2):265–294. doi: 10.1113/jphysiol.1971.sp009432. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boynton R. M., Whitten D. N. Visual adaptation in monkey cones: recordings of late receptor potentials. Science. 1970 Dec 25;170(3965):1423–1426. doi: 10.1126/science.170.3965.1423. [DOI] [PubMed] [Google Scholar]
  3. Cervetto L., MacNichol E. F., Jr Inactivation of horizontal cells in turtle retina by glutamate and aspartate. Science. 1972 Nov 17;178(4062):767–768. doi: 10.1126/science.178.4062.767. [DOI] [PubMed] [Google Scholar]
  4. Dowling J. E., Ripps H. S-potentials in the skate retina. Intracellular recordings during light and dark adaptation. J Gen Physiol. 1971 Aug;58(2):163–189. doi: 10.1085/jgp.58.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dowling J. E., Werblin F. S. Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure. J Neurophysiol. 1969 May;32(3):315–338. doi: 10.1152/jn.1969.32.3.315. [DOI] [PubMed] [Google Scholar]
  6. Ikeda H., Wright M. J. Outer excitatory ('disinhibition') surround to receptive fields of retinal ganglion cells. J Physiol. 1972 Jul;224(1):26P–27P. [PubMed] [Google Scholar]
  7. Kaneko A. Physiological and morphological identification of horizontal, bipolar and amacrine cells in goldfish retina. J Physiol. 1970 May;207(3):623–633. doi: 10.1113/jphysiol.1970.sp009084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Korenbrot J. I., Cone R. A. Dark ionic flux and the effects of light in isolated rod outer segments. J Gen Physiol. 1972 Jul;60(1):20–45. doi: 10.1085/jgp.60.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Matsumoto N., Naka K. I. Identification of intracellular responses in the frog retina. Brain Res. 1972 Jul 13;42(1):59–71. doi: 10.1016/0006-8993(72)90042-x. [DOI] [PubMed] [Google Scholar]
  10. Naka K. I. Computer assisted analysis of S-potentials. Biophys J. 1969 Jun;9(6):845–859. doi: 10.1016/S0006-3495(69)86422-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Naka K. I., Rushton W. A. The generation and spread of S-potentials in fish (Cyprinidae). J Physiol. 1967 Sep;192(2):437–461. doi: 10.1113/jphysiol.1967.sp008308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Naka K. I., Witkovsky P. Dogfish ganglion cell discharge resulting from extrinsic polarization of the horizontal cells. J Physiol. 1972 Jun;223(2):449–460. doi: 10.1113/jphysiol.1972.sp009857. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nelson R. A comparison of electrical properties of neurons in Necturus retina. J Neurophysiol. 1973 May;36(3):519–535. doi: 10.1152/jn.1973.36.3.519. [DOI] [PubMed] [Google Scholar]
  14. Normann R. A., Werblin F. S. Control of retinal sensitivity. I. Light and dark adaptation of vertebrate rods and cones. J Gen Physiol. 1974 Jan;63(1):37–61. doi: 10.1085/jgp.63.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. RATOOSH P., GRAHAM C. H. Areal effects in foveal brightness discrimination. J Exp Psychol. 1951 Dec;42(6):367–375. doi: 10.1037/h0056503. [DOI] [PubMed] [Google Scholar]
  16. Steinberg R. H. Rod and cone contributions to S-potentials from the cat retina. Vision Res. 1969 Nov;9(11):1319–1329. doi: 10.1016/0042-6989(69)90069-8. [DOI] [PubMed] [Google Scholar]
  17. Stell W. K. The structure and relationships of horizontal cells and photoreceptor-bipolar synaptic complexes in goldfish retina. Am J Anat. 1967 Sep;121(2):401–423. doi: 10.1002/aja.1001210213. [DOI] [PubMed] [Google Scholar]
  18. Werblin F. S. Adaptation in a vertebrate retina: intracellular recording in Necturus. J Neurophysiol. 1971 Mar;34(2):228–241. doi: 10.1152/jn.1971.34.2.228. [DOI] [PubMed] [Google Scholar]
  19. Werblin F. S., Copenhagen D. R. Control of retinal sensitivity. 3. Lateral interactions at the inner plexiform layer. J Gen Physiol. 1974 Jan;63(1):88–110. doi: 10.1085/jgp.63.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Werblin F. S., Dowling J. E. Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording. J Neurophysiol. 1969 May;32(3):339–355. doi: 10.1152/jn.1969.32.3.339. [DOI] [PubMed] [Google Scholar]
  21. Werblin F. S. Response of retinal cells to moving spots: intracellular recording in Necturus maculosus. J Neurophysiol. 1970 May;33(3):342–350. doi: 10.1152/jn.1970.33.3.342. [DOI] [PubMed] [Google Scholar]
  22. Westheimer G. Spatial interaction in the human retina during scotopic vision. J Physiol. 1965 Dec;181(4):881–894. doi: 10.1113/jphysiol.1965.sp007803. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Witkovsky P., Nelson J., Ripps H. Action spectra and adaptation properties of carp photoreceptors. J Gen Physiol. 1973 Apr;61(4):401–423. doi: 10.1085/jgp.61.4.401. [DOI] [PMC free article] [PubMed] [Google Scholar]

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