Protein Science 16: 14–19 (2007)
Solution structure of a small protein containing a fluorinated side chain in the core
Gabriel Cornilescu, Erik B. Hadley, Matthew G. Woll, John L. Markley, Samuel H. Gellman, and Claudia C. Cornilescu
We, the authors, retract the claim that the structure reported is the first to include a fluorinated side chain. A number of prior structures that contain side chains bearing a single H → F substitution have been reported, and we regret not having cited these (Ji et al. 1994, 1997; Xiao et al. 1998; Minks et al. 1999; Rozovsky et al. 2001; Campos-Olivas et al. 2002; Alexeev et al. 2003; Bae et al. 2004; Ayala et al. 2005; Wang et al. 2005). To our knowledge, however, ours is the first report of a protein structure containing a more heavily fluorinated side chain (bearing at least three F atoms), for which non-negligible structural rearrangements may be expected.
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