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. 1963 Aug;50(2):355–362. doi: 10.1073/pnas.50.2.355

A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS*,†

V N Iyer 1,2,3, W Szybalski 1,2,3
PMCID: PMC221180  PMID: 14060656

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALASSA G. [Effect of mitomycin C on the transformation of Pneumococcus]. Ann Inst Pasteur (Paris) 1962 May;102:547–555. [PubMed] [Google Scholar]
  2. CHEER S., TCHEN T. T. Effect of mitomycin C on the synthesis of induced bita-galactosidase in E. coli. Biochem Biophys Res Commun. 1962 Oct 17;9:271–274. doi: 10.1016/0006-291x(62)90072-4. [DOI] [PubMed] [Google Scholar]
  3. COOPER S., ZINDER N. D. The growth of an RNA bacteriophage: the role of DNA synthesis. Virology. 1962 Nov;18:405–411. doi: 10.1016/0042-6822(62)90031-4. [DOI] [PubMed] [Google Scholar]
  4. GEIDUSCHEK E. P. On the factors controlling the reversibility of DNA denaturation. J Mol Biol. 1962 Jun;4:467–487. doi: 10.1016/s0022-2836(62)80103-x. [DOI] [PubMed] [Google Scholar]
  5. HATA T., HOSHI T., KANAMORI K., MATSUMAE A., SANO Y., SHIMA T., SUGAWARA R. Mitomycin, a new antibiotic from Streptomyces. I. J Antibiot (Tokyo) 1956 Jul;9(4):141–146. [PubMed] [Google Scholar]
  6. KERSTEN H., RAUEN H. M. Degradation of deoxyribonucleic acid in Escherichia coli cells treated with mitomycin C. Nature. 1961 Jun 24;190:1195–1196. doi: 10.1038/1901195a0. [DOI] [PubMed] [Google Scholar]
  7. KORN D., WEISSBACH A. Thymineless induction in Escherichia coli K12 (lambda). Biochim Biophys Acta. 1962 Nov 26;61:775–790. doi: 10.1016/0926-6550(62)90060-9. [DOI] [PubMed] [Google Scholar]
  8. KOZINSKI A. W. Fragmentary transfer of P32-labeled parental DNA to progeny phage. Virology. 1961 Jan;13:124–134. doi: 10.1016/0042-6822(61)90039-3. [DOI] [PubMed] [Google Scholar]
  9. LERMAN L. S. Structural considerations in the interaction of DNA and acridines. J Mol Biol. 1961 Feb;3:18–30. doi: 10.1016/s0022-2836(61)80004-1. [DOI] [PubMed] [Google Scholar]
  10. MAGEE W. E., MILLER O. V. Dissociation of the synthesis of host and viral deoxyribonucleic acid. Biochim Biophys Acta. 1962 Jun 11;55:818–826. doi: 10.1016/0006-3002(62)90894-6. [DOI] [PubMed] [Google Scholar]
  11. MARMUR J., GROSSMAN L. Ultraviolet light induced linking of deoxyribonucleic acid strands and its reversal by photoreactivating enzyme. Proc Natl Acad Sci U S A. 1961 Jun 15;47:778–787. doi: 10.1073/pnas.47.6.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NAKATA Y., NAKATA K., SAKAMOTO Y. On the action mechanism of mitomycin C. Biochem Biophys Res Commun. 1961 Dec 20;6:339–343. doi: 10.1016/0006-291x(61)90141-3. [DOI] [PubMed] [Google Scholar]
  13. OPARA-KUBINSKA Z., KURYLO-BOROWSKA Z., SZYBALSKI W. Genetic transformation studies. II. Effect of ultraviolet light on the molecular properties of normal and halogenated deoxyribonucleic acid. Biochim Biophys Acta. 1963 Jun 25;72:298–309. doi: 10.1016/0006-3002(63)90245-2. [DOI] [PubMed] [Google Scholar]
  14. OTSUJI N., SEKIGUCHI M., IIJIMA T., TAKAGI Y. Induction of phage formation in the lysogenic Escherichia coli K-12 by mitomycin C. Nature. 1959 Oct 3;184(Suppl 14):1079–1080. doi: 10.1038/1841079b0. [DOI] [PubMed] [Google Scholar]
  15. REICH E., SHATKIN A. J., TATUM E. L. Bacteriocidal action of mitomycin C. Biochim Biophys Acta. 1960 Dec 18;45:608–610. doi: 10.1016/0006-3002(60)91504-3. [DOI] [PubMed] [Google Scholar]
  16. SEKIGUCHI M., TAKAGI Y. Synthesis of deoxyribonucleic acid by phage-infected Escherichia coli in presence of mitomycin C. Nature. 1959 Apr 18;183(4668):1134–1135. doi: 10.1038/1831134a0. [DOI] [PubMed] [Google Scholar]
  17. SHATKIN A. J., REICH E., FRANKLIN R. M., TATUM E. L. Effect of mitomycin C on mammalian cells in culture. Biochim Biophys Acta. 1962 Mar 5;55:277–289. doi: 10.1016/0006-3002(62)90783-7. [DOI] [PubMed] [Google Scholar]
  18. SHIBA S., TERAWAKI A., TAGUCHI T., KAWAMATA J. Selective inhibition of formation of deoxyribonucleic acid in Escherichia coli by mitomycin C. Nature. 1959 Apr 11;183(4667):1056–1057. doi: 10.1038/1831056a0. [DOI] [PubMed] [Google Scholar]
  19. SPIZIZEN J. Genetic activity of deoxyribonucleic acid in the reconstitution of biosynthetic pathways. Fed Proc. 1959 Dec;18:957–965. [PubMed] [Google Scholar]
  20. SUGIURA K. Studies in a tumor spectrum. VIII. The effect of mitomycin C on the growth of a variety of mouse, rat, and hamster tumors. Cancer Res. 1959 May;19(4):438–445. [PubMed] [Google Scholar]
  21. SZYBALSKI W., ERIKSON R. L., GENTRY G. A., GAFFORD L. G., RANDALL C. C. Unusual properties of fowlpox virus DNA. Virology. 1963 Apr;19:586–589. doi: 10.1016/0042-6822(63)90056-4. [DOI] [PubMed] [Google Scholar]
  22. SZYBALSKI W. Special microbiological systems. II. Observations on chemical mutagenesis in microorganisms. Ann N Y Acad Sci. 1958 Dec 5;76(3):475–489. doi: 10.1111/j.1749-6632.1958.tb57106.x. [DOI] [PubMed] [Google Scholar]

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