Abstract
Two cutaneous papillomas produced with the Shope virus in adult domestic rabbits were transferred to their leg muscles and thence to those of several successive groups of rabbits of various ages. The growths failed to establish themselves in some newborn animals, but in many formed huge masses, immobilizing the legs with result in early death. Not infrequently they did well for months after their hosts had matured, yet nevertheless they failed regularly on further transfer in adults. They were eventually lost because left long prior to passage on the supposition that they might gain the ability to succeed in mature hosts. The papillomas when growing actively sometimes penetrated the reactive tissue encapsulating them and replaced the adjacent muscle. They often entered lymph and blood vessels but never metastasized, nor did they undergo carcinomatous change though their total period of proliferation was as considerable as that elapsing in many instances before cancer appeared in papillomas produced by the same virus material and left on the skin.
Full Text
The Full Text of this article is available as a PDF (803.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beard J. W., Rous P. A VIRUS-INDUCED MAMMALIAN GROWTH WITH THE CHARACTERS OF A TUMOR (THE SHOPE RABBIT PAPILLOMA) : II. EXPERIMENTAL ALTERATIONS OF THE GROWTH ON THE SKIN: MORPHOLOGICAL CONSIDERATIONS: THE PHENOMENA OF RETROGRESSION. J Exp Med. 1934 Nov 30;60(6):723–740. doi: 10.1084/jem.60.6.723. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rous P., Beard J. W. THE PROGRESSION TO CARCINOMA OF VIRUS-INDUCED RABBIT PAPILLOMAS (SHOPE). J Exp Med. 1935 Sep 30;62(4):523–548. doi: 10.1084/jem.62.4.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH W. E., KIDD J. G., ROUS P. Experiments on the cause of the rabbit carcinomas derived from virus-induced papillomas. I. Propagation of several of the cancers in sucklings, with etiological tests. J Exp Med. 1952 Mar;95(3):299–318. doi: 10.1084/jem.95.3.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shope R. E., Hurst E. W. INFECTIOUS PAPILLOMATOSIS OF RABBITS : WITH A NOTE ON THE HISTOPATHOLOGY. J Exp Med. 1933 Oct 31;58(5):607–624. doi: 10.1084/jem.58.5.607. [DOI] [PMC free article] [PubMed] [Google Scholar]