Abstract
The injection of tetraethylammonium chloride into the giant axon of the squid prolongs the action potential and eliminates most of the late current under voltage-clamp. Experiments on fibers in an external medium of high potassium ion concentration demonstrate that injected tetraethylammonium chloride causes rectification of the instantaneous current-voltage curve for potassium by excluding outward current. This interference with the flow of outward potassium ion current underlies the prolongation of the action potential seen in tetraethylammonium-injected fibers.
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Selected References
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- ADELMAN W. J., TAYLOR R. E. Leakage current rectification in the squid giant axon. Nature. 1961 Jun 3;190:883–885. doi: 10.1038/190883a0. [DOI] [PubMed] [Google Scholar]
- ARMSTRONG C. M., BINSTOCK L. THE EFFECTS OF SEVERAL ALCOHOLS ON THE PROPERTIES OF THE SQUID GIANT AXON. J Gen Physiol. 1964 Nov;48:265–277. doi: 10.1085/jgp.48.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
- COLE K. S., MOORE J. W. Ionic current measurements in the squid giant axon membrane. J Gen Physiol. 1960 Sep;44:123–167. doi: 10.1085/jgp.44.1.123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FITZHUGH R. Thresholds and plateaus in the Hodgkin-Huxley nerve equations. J Gen Physiol. 1960 May;43:867–896. doi: 10.1085/jgp.43.5.867. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GEORGE E. P., JOHNSON E. A. Solutions of the Hodgkin-Huxley equations for squid axon treated with tetraethylammonium and in potassium-rich media. Aust J Exp Biol Med Sci. 1961 Jun;39:275–293. doi: 10.1038/icb.1961.28. [DOI] [PubMed] [Google Scholar]
- HODGKIN A. L., HOROWICZ P. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J Physiol. 1959 Oct;148:127–160. doi: 10.1113/jphysiol.1959.sp006278. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J Physiol. 1952 Apr;116(4):449–472. doi: 10.1113/jphysiol.1952.sp004717. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F., KATZ B. Measurement of current-voltage relations in the membrane of the giant axon of Loligo. J Physiol. 1952 Apr;116(4):424–448. doi: 10.1113/jphysiol.1952.sp004716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. The components of membrane conductance in the giant axon of Loligo. J Physiol. 1952 Apr;116(4):473–496. doi: 10.1113/jphysiol.1952.sp004718. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., HUXLEY A. F. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J Physiol. 1952 Apr;116(4):497–506. doi: 10.1113/jphysiol.1952.sp004719. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., KATZ B. The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol. 1949 Mar 1;108(1):37–77. doi: 10.1113/jphysiol.1949.sp004310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NOBLE D. A modification of the Hodgkin--Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J Physiol. 1962 Feb;160:317–352. doi: 10.1113/jphysiol.1962.sp006849. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TASAKI I. Demonstration of two stable states of the nerve membrane in potassium-rich media. J Physiol. 1959 Oct;148:306–331. doi: 10.1113/jphysiol.1959.sp006290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TASAKI I., HAGIWAR A. S. Demonstration of two stable potential states in the squid giant axon under tetraethylammonium chloride. J Gen Physiol. 1957 Jul 20;40(6):859–885. doi: 10.1085/jgp.40.6.859. [DOI] [PMC free article] [PubMed] [Google Scholar]