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Canadian Family Physician logoLink to Canadian Family Physician
. 2003 Jun;49:769–773.

Preconception care for women with type 1 diabetes.

Jennifer Klinke 1, Ellen L Toth 1
PMCID: PMC2214237  PMID: 12836865

Abstract

OBJECTIVE: To emphasize preconception care of women with type 1 diabetes and the role of primary care physicians in evaluating and counseling them. QUALITY OF EVIDENCE: Substantial level II evidence indicates that tight glycemic control before conception and early in pregnancy reduces the rate of congenital malformations. Most evidence concerning maternal and fetal risks during pregnancy in patients with type 1 diabetes is level III or IV. Little is published on the role of family physicians in providing preconception counseling or care. MAIN MESSAGE: Preconception care is effective in improving glycemic control early in pregnancy and in reducing the rate of congenital malformations. Preconception evaluation of type 1 diabetic patients involves assessment of prepregnancy glycemic control and diabetic complications. Preconception counseling includes discussing the rate of transmission of diabetes, the effects of pregnancy on maternal and fetal complications, and the use of contraception until optimal glycemic control can be attained. CONCLUSION: Primary care physicians often have frequent and early contact with women of reproductive age; they are ideal candidates for providing type 1 diabetic women with preconception evaluation and counseling.

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Selected References

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  1. Chew E. Y., Mills J. L., Metzger B. E., Remaley N. A., Jovanovic-Peterson L., Knopp R. H., Conley M., Rand L., Simpson J. L., Holmes L. B. Metabolic control and progression of retinopathy. The Diabetes in Early Pregnancy Study. National Institute of Child Health and Human Development Diabetes in Early Pregnancy Study. Diabetes Care. 1995 May;18(5):631–637. doi: 10.2337/diacare.18.5.631. [DOI] [PubMed] [Google Scholar]
  2. Dunne F. P., Brydon P., Smith T., Essex M., Nicholson H., Dunn J. Pre-conception diabetes care in insulin-dependent diabetes mellitus. QJM. 1999 Mar;92(3):175–176. doi: 10.1093/qjmed/92.3.175. [DOI] [PubMed] [Google Scholar]
  3. Greene M. F. Spontaneous abortions and major malformations in women with diabetes mellitus. Semin Reprod Endocrinol. 1999;17(2):127–136. doi: 10.1055/s-2007-1016220. [DOI] [PubMed] [Google Scholar]
  4. Holing E. V., Beyer C. S., Brown Z. A., Connell F. A. Why don't women with diabetes plan their pregnancies? Diabetes Care. 1998 Jun;21(6):889–895. doi: 10.2337/diacare.21.6.889. [DOI] [PubMed] [Google Scholar]
  5. Holing E. V. Preconception care of women with diabetes: the unrevealed obstacles. J Matern Fetal Med. 2000 Jan-Feb;9(1):10–13. doi: 10.1002/(SICI)1520-6661(200001/02)9:1<10::AID-MFM4>3.0.CO;2-Z. [DOI] [PubMed] [Google Scholar]
  6. Janz N. K., Herman W. H., Becker M. P., Charron-Prochownik D., Shayna V. L., Lesnick T. G., Jacober S. J., Fachnie J. D., Kruger D. F., Sanfield J. A. Diabetes and pregnancy. Factors associated with seeking pre-conception care. Diabetes Care. 1995 Feb;18(2):157–165. doi: 10.2337/diacare.18.2.157. [DOI] [PubMed] [Google Scholar]
  7. Jovanovic L., Druzin M., Peterson C. M. Effect of euglycemia on the outcome of pregnancy in insulin-dependent diabetic women as compared with normal control subjects. Am J Med. 1981 Dec;71(6):921–927. doi: 10.1016/0002-9343(81)90301-6. [DOI] [PubMed] [Google Scholar]
  8. Kitzmiller J. L., Buchanan T. A., Kjos S., Combs C. A., Ratner R. E. Pre-conception care of diabetes, congenital malformations, and spontaneous abortions. Diabetes Care. 1996 May;19(5):514–541. doi: 10.2337/diacare.19.5.514. [DOI] [PubMed] [Google Scholar]
  9. Kitzmiller J. L., Gavin L. A., Gin G. D., Jovanovic-Peterson L., Main E. K., Zigrang W. D. Preconception care of diabetes. Glycemic control prevents congenital anomalies. JAMA. 1991 Feb 13;265(6):731–736. [PubMed] [Google Scholar]
  10. Klein B. E., Moss S. E., Klein R. Effect of pregnancy on progression of diabetic retinopathy. Diabetes Care. 1990 Jan;13(1):34–40. doi: 10.2337/diacare.13.1.34. [DOI] [PubMed] [Google Scholar]
  11. Leguizamon G., Reece E. A. Effect of medical therapy on progressive nephropathy: influence of pregnancy, diabetes and hypertension. J Matern Fetal Med. 2000 Jan-Feb;9(1):70–78. doi: 10.1002/(SICI)1520-6661(200001/02)9:1<70::AID-MFM15>3.0.CO;2-#. [DOI] [PubMed] [Google Scholar]
  12. Lunt H. Women and diabetes. Diabet Med. 1996 Dec;13(12):1009–1016. doi: 10.1002/(SICI)1096-9136(199612)13:12<1009::AID-DIA281>3.0.CO;2-U. [DOI] [PubMed] [Google Scholar]
  13. Magee L. A. Treating hypertension in women of child-bearing age and during pregnancy. Drug Saf. 2001;24(6):457–474. doi: 10.2165/00002018-200124060-00004. [DOI] [PubMed] [Google Scholar]
  14. McElvy S. S., Miodovnik M., Rosenn B., Khoury J. C., Siddiqi T., Dignan P. S., Tsang R. C. A focused preconceptional and early pregnancy program in women with type 1 diabetes reduces perinatal mortality and malformation rates to general population levels. J Matern Fetal Med. 2000 Jan-Feb;9(1):14–20. doi: 10.1002/(SICI)1520-6661(200001/02)9:1<14::AID-MFM5>3.0.CO;2-K. [DOI] [PubMed] [Google Scholar]
  15. Ryan E. A. Pregnancy in diabetes. Med Clin North Am. 1998 Jul;82(4):823–845. doi: 10.1016/s0025-7125(05)70026-2. [DOI] [PubMed] [Google Scholar]
  16. Suhonen L., Hiilesmaa V., Teramo K. Glycaemic control during early pregnancy and fetal malformations in women with type I diabetes mellitus. Diabetologia. 2000 Jan;43(1):79–82. doi: 10.1007/s001250050010. [DOI] [PubMed] [Google Scholar]
  17. Tuomilehto J., Podar T., Tuomilehto-Wolf E., Virtala E. Evidence for importance of gender and birth cohort for risk of IDDM in offspring of IDDM parents. Diabetologia. 1995 Aug;38(8):975–982. doi: 10.1007/BF00400588. [DOI] [PubMed] [Google Scholar]
  18. Willhoite M. B., Bennert H. W., Jr, Palomaki G. E., Zaremba M. M., Herman W. H., Williams J. R., Spear N. H. The impact of preconception counseling on pregnancy outcomes. The experience of the Maine Diabetes in Pregnancy Program. Diabetes Care. 1993 Feb;16(2):450–455. doi: 10.2337/diacare.16.2.450. [DOI] [PubMed] [Google Scholar]

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