Abstract
The identified interneuron L10 in the abdominal ganglion of Aplysia was stimulated to fire action potentials in a random sequence while the early inhibitory potential of its follower cell L2 was recorded. Application of Wiener nonlinear analysis to these data yielded a predictive model of the facilitating postsynaptic potential. The model shows that facilitation changes both the time-course and the magnitude of the early synaptic potential. The facilitated response has a longer duration than the unfacilitated response. Its magnitude is exponentially decreasing with increasing interstimulus interval between test and conditioning stimuli. Facilitation is abolished at short interstimulus intervals. The hypothesis that the magnitude only of transmitter release is increased cannot explain these results. The observed facilitation may be due to characteristics of pre- and postsynaptic morphology.
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Selected References
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- DEL CASTILLO J., KATZ B. Statistical factors involved in neuromuscular facilitation and depression. J Physiol. 1954 Jun 28;124(3):574–585. doi: 10.1113/jphysiol.1954.sp005130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kehoe J. S., Ascher P. Re-evaluation of the synaptic activation of an electrogenic sodium pump. Nature. 1970 Feb 28;225(5235):820–823. doi: 10.1038/225820a0. [DOI] [PubMed] [Google Scholar]
- Krausz H. I., Friesen W. O. The analysis of nonlinear synaptic transmission. J Gen Physiol. 1977 Aug;70(2):243–265. doi: 10.1085/jgp.70.2.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kroeker J. P. Wiener analysis of nonlinear systems using Poisson-Charlier crosscorrelation. Biol Cybern. 1977 Oct 14;27(4):221–227. doi: 10.1007/BF00344143. [DOI] [PubMed] [Google Scholar]
- Parnas I., Hochstein S., Parnas H. Theoretical analysis of parameters leading to frequency modulation along an inhomogeneous axon. J Neurophysiol. 1976 Jul;39(4):909–923. doi: 10.1152/jn.1976.39.4.909. [DOI] [PubMed] [Google Scholar]
- Pinsker H., Kandel E. R. Synaptic activation of an electrogenic sodium pump. Science. 1969 Feb 28;163(3870):931–935. doi: 10.1126/science.163.3870.931. [DOI] [PubMed] [Google Scholar]
- Rahamimoff R. A dual effect of calcium ions on neuromuscular facilitation. J Physiol. 1968 Mar;195(2):471–480. doi: 10.1113/jphysiol.1968.sp008468. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Winlow W., Kandel E. R. The morphology of identified neurons in the abdominal ganglion of Aplysia californica. Brain Res. 1976 Aug 13;112(2):221–249. doi: 10.1016/0006-8993(76)90282-1. [DOI] [PubMed] [Google Scholar]
- Yau K. W. Receptive fields, geometry and conduction block of sensory neurones in the central nervous system of the leech. J Physiol. 1976 Dec;263(3):513–538. doi: 10.1113/jphysiol.1976.sp011643. [DOI] [PMC free article] [PubMed] [Google Scholar]