Skip to main content
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1982 Nov;152(2):880–887. doi: 10.1128/jb.152.2.880-887.1982

Lipid synthesis during morphogenesis of Mucor racemosus.

E T Ito, R L Cihlar, C B Inderlied
PMCID: PMC221543  PMID: 7130131

Abstract

Lipid synthesis increases coordinately with protein and RNA synthesis during morphogenesis of Mucor racemosus. The lipid synthesis inhibitor cerulenin can completely block morphogenesis under conditions in which cell growth continues. An increase in phospholipid turnover may be an important correlate to morphogenesis of Mucor spp., especially the turnover of phosphotidyl inositol and phosphatidyl ethanolamine. The increase in ornithine decarboxylase, which occurs during morphogenesis, is inhibited by the addition of cerulenin.

Full text

PDF
880

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTNICKI-GARCIA S., NICKERSON W. J. Induction of yeast-like development in Mucor by carbon dioxide. J Bacteriol. 1962 Oct;84:829–840. doi: 10.1128/jb.84.4.829-840.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bednarz-Prashad A. J., Mize C. E. Phospholipid, enzymatic, and polypeptide analyses of the mitochondrial membranes from Saccharomyces carlsbergensis. Biochemistry. 1978 Oct 3;17(20):4178–4186. doi: 10.1021/bi00613a011. [DOI] [PubMed] [Google Scholar]
  3. Brambl R., Wenzler H., Josephson M. Mitochondrial biogenesis during fungal spore germination: effects of the antilipogenic antibiotic cerulenin upon Botryodiplodia spores. J Bacteriol. 1978 Aug;135(2):311–317. doi: 10.1128/jb.135.2.311-317.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. De Silva N. S., Siu C. H. Preferential incorporation of phospholipids into plasma membranes during cell aggregation of Dictyostelium discoideum. J Biol Chem. 1980 Sep 25;255(18):8489–8496. [PubMed] [Google Scholar]
  5. Gordon P. A., Stewart P. R., Clark-Walker G. D. Fatty acid and sterol composition of Mucor genevensis in relation to dimorphism and anaerobic growth. J Bacteriol. 1971 Jul;107(1):114–120. doi: 10.1128/jb.107.1.114-120.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hiatt W. R., Inderlied C. B., Sypherd P. S. Differential synthesis of polypeptides during morphogenesis of Mucor. J Bacteriol. 1980 Mar;141(3):1350–1359. doi: 10.1128/jb.141.3.1350-1359.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Inderlied C. B., Cihlar R. L., Sypherd P. S. Regulation of ornithine decarboxylase during morphogenesis of Mucor racemosus. J Bacteriol. 1980 Feb;141(2):699–706. doi: 10.1128/jb.141.2.699-706.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Larsen A. D., Sypherd P. S. Cyclic adenosine 3',5'-monophosphate and morphogenesis in Mucor racemosus. J Bacteriol. 1974 Feb;117(2):432–438. doi: 10.1128/jb.117.2.432-438.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McIntyre T. M., Chamberlain B. K., Webster R. E., Bell R. M. Mutants of Escherichia coli defective in membrane phospholipid synthesis. Effects of cessation and reinitiation of phospholipid synthesis on macromolecular synthesis and phospholipid turnover. J Biol Chem. 1977 Jul 10;252(13):4487–4493. [PubMed] [Google Scholar]
  10. Mooney D. T., Sypherd P. S. Volatile factor involved in the dimorphism of Mucor racemosus. J Bacteriol. 1976 Jun;126(3):1266–1270. doi: 10.1128/jb.126.3.1266-1270.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ohno T., Awaya J., Omura S. Inhibition of sporulation by cerulenin and its reversion by exogenous fatty acids in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 1976 Jan;9(1):42–48. doi: 10.1128/aac.9.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Omura S. The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis. Bacteriol Rev. 1976 Sep;40(3):681–697. doi: 10.1128/br.40.3.681-697.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Orlowski M., Sypherd P. S. Protein synthesis during morphogenesis of Mucor racemosus. J Bacteriol. 1977 Oct;132(1):209–218. doi: 10.1128/jb.132.1.209-218.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Orlowski M., Sypherd P. S. RNA synthesis during morphogenesis of the fungus Mucor racemosus. Arch Microbiol. 1978 Nov 13;119(2):145–152. doi: 10.1007/BF00964265. [DOI] [PubMed] [Google Scholar]
  15. Ross E., Schatz G. Assay of protein in the presence of high concentrations of sulfhydryl compounds. Anal Biochem. 1973 Jul;54(1):304–306. doi: 10.1016/0003-2697(73)90280-7. [DOI] [PubMed] [Google Scholar]
  16. Sissons C. H. Improved technique for accurate and convenient assay of biological reactions liberating 14CO2. Anal Biochem. 1976 Feb;70(2):454–462. doi: 10.1016/0003-2697(76)90470-x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES