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. 1983 Feb;153(2):1079–1082. doi: 10.1128/jb.153.2.1079-1082.1983

Escherichia coli xth mutants are hypersensitive to hydrogen peroxide.

B Demple, J Halbrook, S Linn
PMCID: PMC221738  PMID: 6337115

Abstract

Escherichia coli mutants lacking exonuclease III (xthA) are exceptionally sensitive to hydrogen peroxide. They are killed by H2O2 at 20 times the rate of wild-type bacteria and at 3 to 4 times the rate of recA cells. This is the first clear phenotypic sensitivity reported for xth- E. coli and should aid in clarifying peroxide-induced lethality and the in vivo role of exonuclease III.

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Selected References

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