Abstract
HTLV-1, or human T-lymphotropic virus type 1, is a retrovirus causing disease in humans. Responsible for adult T-cell leukemia/lymphoma, it is the first documented viral-induced neoplasia in humans. This same virus has recently been implicated in a progressive neurological disorder, and because it is transmissible by blood transfusion, it represents a major problem in blood banking. The relationship of this virus to other newly discovered retroviruses is discussed.
Keywords: HTLV-1, adult T-cell leukemia/lymphoma, blood transfusion
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bhagavati S., Ehrlich G., Kula R. W., Kwok S., Sninsky J., Udani V., Poiesz B. J. Detection of human T-cell lymphoma/leukemia virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy. N Engl J Med. 1988 May 5;318(18):1141–1147. doi: 10.1056/NEJM198805053181801. [DOI] [PubMed] [Google Scholar]
- Bove J. R., Sandler S. G. HTLV-1 and blood transfusion. Transfusion. 1988 Mar-Apr;28(2):93–94. doi: 10.1046/j.1537-2995.1988.28288179037.x. [DOI] [PubMed] [Google Scholar]
- Broder S., Bunn P. A., Jr, Jaffe E. S., Blattner W., Gallo R. C., Wong-Staal F., Waldmann T. A., DeVita V. T., Jr NIH conference. T-cell lymphoproliferative syndrome associated with human T-cell leukemia/lymphoma virus. Ann Intern Med. 1984 Apr;100(4):543–557. doi: 10.7326/0003-4819-100-4-543. [DOI] [PubMed] [Google Scholar]
- Kim J. H., Durack D. T. Manifestations of human T-lymphotropic virus type I infection. Am J Med. 1988 May;84(5):919–928. doi: 10.1016/0002-9343(88)90072-1. [DOI] [PubMed] [Google Scholar]
- Kuefler P. R., Bunn P. A., Jr Adult T cell leukaemia/lymphoma. Clin Haematol. 1986 Aug;15(3):695–726. [PubMed] [Google Scholar]
- Poiesz B. J., Ruscetti F. W., Gazdar A. F., Bunn P. A., Minna J. D., Gallo R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415–7419. doi: 10.1073/pnas.77.12.7415. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rice G. P., Armstrong H. A., Bulman D. E., Paty D. W., Ebers G. C. Absence of antibody to HTLV I and III in sera of Canadian patients with multiple sclerosis and chronic myelopathy. Ann Neurol. 1986 Oct;20(4):533–534. doi: 10.1002/ana.410200415. [DOI] [PubMed] [Google Scholar]
- Román G. C. Retrovirus-associated myelopathies. Arch Neurol. 1987 Jun;44(6):659–663. doi: 10.1001/archneur.1987.00520180073022. [DOI] [PubMed] [Google Scholar]
- Uchiyama T., Yodoi J., Sagawa K., Takatsuki K., Uchino H. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood. 1977 Sep;50(3):481–492. [PubMed] [Google Scholar]
- Varmus H. Retroviruses. Science. 1988 Jun 10;240(4858):1427–1435. doi: 10.1126/science.3287617. [DOI] [PubMed] [Google Scholar]
- Williams A. E., Fang C. T., Slamon D. J., Poiesz B. J., Sandler S. G., Darr W. F., 2nd, Shulman G., McGowan E. I., Douglas D. K., Bowman R. J. Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood donors. Science. 1988 Apr 29;240(4852):643–646. doi: 10.1126/science.2896386. [DOI] [PubMed] [Google Scholar]
- Wong-Staal F., Gallo R. C. The family of human T-lymphotropic leukemia viruses: HTLV-I as the cause of adult T cell leukemia and HTLV-III as the cause of acquired immunodeficiency syndrome. Blood. 1985 Feb;65(2):253–263. [PubMed] [Google Scholar]