Abstract
Newer techniques for diagnosing early pregnancy have shown that post-implantation embryo loss may be four times the accepted rate of 15%-20%. This article describes various causes of spontaneous abortion and its clinical evaluation and treatment, and proffers suggestions for answering the questions of women who have experienced this loss.
Keywords: miscarriage, pregnancy loss, etiology, management
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Selected References
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- Anderson S. G. Management of threatened abortion with real-time sonography. Obstet Gynecol. 1980 Feb;55(2):259–262. [PubMed] [Google Scholar]
- Ayers J. W., Peterson E. P., Ansbacher R. Early therapy for the incompetent cervix in patients with habitual abortion. Fertil Steril. 1982 Aug;38(2):177–181. doi: 10.1016/s0015-0282(16)46455-1. [DOI] [PubMed] [Google Scholar]
- Balasch J., Creus M., Vanrell J. A. Luteal function after delayed ovulation. Fertil Steril. 1986 Mar;45(3):342–344. doi: 10.1016/s0015-0282(16)49214-9. [DOI] [PubMed] [Google Scholar]
- Cooper J. M., Houck R. M., Rigberg H. S. The incidence of intrauterine abnormalities found at hysteroscopy in patients undergoing elective hysteroscopic sterilization. J Reprod Med. 1983 Oct;28(10):659–661. [PubMed] [Google Scholar]
- Daly D. C., Walters C. A., Soto-Albors C. E., Riddick D. H. Endometrial biopsy during treatment of luteal phase defects is predictive of therapeutic outcome. Fertil Steril. 1983 Sep;40(3):305–310. doi: 10.1016/s0015-0282(16)47291-2. [DOI] [PubMed] [Google Scholar]
- Dandekar P. V., Quigley M. M. Laboratory setup for human in vitro fertilization. Fertil Steril. 1984 Jul;42(1):1–12. doi: 10.1016/s0015-0282(16)47949-5. [DOI] [PubMed] [Google Scholar]
- Dawson D. W., Sawers A. H. Infertility and folate deficiency. Case reports. Br J Obstet Gynaecol. 1982 Aug;89(8):678–680. doi: 10.1111/j.1471-0528.1982.tb04726.x. [DOI] [PubMed] [Google Scholar]
- DiZerega G. S., Hodgen G. D. Luteal phase dysfunction infertility: a sequel to aberrant folliculogenesis. Fertil Steril. 1981 May;35(5):489–499. doi: 10.1016/s0015-0282(16)45488-9. [DOI] [PubMed] [Google Scholar]
- Dmowski W. P., Greenblatt R. B. Asherman's syndrome and risk of placenta accreta. Obstet Gynecol. 1969 Aug;34(2):288–299. [PubMed] [Google Scholar]
- Edmonds D. K., Lindsay K. S., Miller J. F., Williamson E., Wood P. J. Early embryonic mortality in women. Fertil Steril. 1982 Oct;38(4):447–453. [PubMed] [Google Scholar]
- Harger J. H., Archer D. F., Marchese S. G., Muracca-Clemens M., Garver K. L. Etiology of recurrent pregnancy losses and outcome of subsequent pregnancies. Obstet Gynecol. 1983 Nov;62(5):574–581. [PubMed] [Google Scholar]
- Hook E. B. Chromosome abnormalities and spontaneous fetal death following amniocentesis: further data and associations with maternal age. Am J Hum Genet. 1983 Jan;35(1):110–116. [PMC free article] [PubMed] [Google Scholar]
- JONES G. E. S., DELFS E. Endocrine patterns in term pregnancies following abortion. J Am Med Assoc. 1951 Jul 28;146(13):1212–1218. doi: 10.1001/jama.1951.03670130034010. [DOI] [PubMed] [Google Scholar]
- Jacobs P. A. Epidemiology of chromosome abnormalities in man. Am J Epidemiol. 1977 Mar;105(3):180–191. doi: 10.1093/oxfordjournals.aje.a112374. [DOI] [PubMed] [Google Scholar]
- MACNAUGHTON M. C. THE PROBABILITY OF RECURRENT ABORTION. J Obstet Gynaecol Br Commonw. 1964 Oct;71:784–784. doi: 10.1111/j.1471-0528.1964.tb04358.x. [DOI] [PubMed] [Google Scholar]
- Metzger D. A., Olive D. L., Stohs G. F., Franklin R. R. Association of endometriosis and spontaneous abortion: effect of control group selection. Fertil Steril. 1986 Jan;45(1):18–22. doi: 10.1016/s0015-0282(16)49090-4. [DOI] [PubMed] [Google Scholar]
- Miller J. F., Williamson E., Glue J., Gordon Y. B., Grudzinskas J. G., Sykes A. Fetal loss after implantation. A prospective study. Lancet. 1980 Sep 13;2(8194):554–556. doi: 10.1016/s0140-6736(80)91991-1. [DOI] [PubMed] [Google Scholar]
- Miodovnik M., Skillman C., Holroyde J. C., Butler J. B., Wendel J. S., Siddiqi T. A. Elevated maternal glycohemoglobin in early pregnancy and spontaneous abortion among insulin-dependent diabetic women. Am J Obstet Gynecol. 1985 Oct 15;153(4):439–442. doi: 10.1016/0002-9378(85)90083-3. [DOI] [PubMed] [Google Scholar]
- Nordenson I. Increased frequencies of chromosomal abnormalities in families with a history of fetal wastage. Clin Genet. 1981 Mar;19(3):168–173. doi: 10.1111/j.1399-0004.1981.tb00691.x. [DOI] [PubMed] [Google Scholar]
- Pernoll M. L. Abortion induced by chemicals encountered in the environment. Clin Obstet Gynecol. 1986 Dec;29(4):953–958. doi: 10.1097/00003081-198612000-00019. [DOI] [PubMed] [Google Scholar]
- Phung Thi Tho, Byrd J. R., McDonough P. G. Etiologies and subsequent reproductive performance of 100 couples with recurrent abortion. Fertil Steril. 1979 Oct;32(4):389–395. [PubMed] [Google Scholar]
- Poland B. J., Yuen B. H. Embryonic development in consecutive specimens from recurrent spontaneous abortions. Am J Obstet Gynecol. 1978 Mar 1;130(5):512–515. doi: 10.1016/0002-9378(78)90068-6. [DOI] [PubMed] [Google Scholar]
- Problems of early pregnancy. Eur J Obstet Gynecol Reprod Biol. 1987 Feb;24(2):123–131. [PubMed] [Google Scholar]
- RABAU E., DAVID A. INTRAUTERINE ADHESIONS: ETIOLOGY, PREVENTION, AND TREATMENT. Obstet Gynecol. 1963 Nov;22:626–629. [PubMed] [Google Scholar]
- Rock J. A., Zacur H. A. The clinical management of repeated early pregnancy wastage. Fertil Steril. 1983 Feb;39(2):123–140. doi: 10.1016/s0015-0282(16)46809-3. [DOI] [PubMed] [Google Scholar]
- Rocklin R. E., Kitzmiller J. L., Carpenter C. B., Garovoy M. R., David J. R. Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. N Engl J Med. 1976 Nov 25;295(22):1209–1213. doi: 10.1056/NEJM197611252952201. [DOI] [PubMed] [Google Scholar]
- Rolfe B. E. Detection of fetal wastage. Fertil Steril. 1982 May;37(5):655–660. doi: 10.1016/s0015-0282(16)46278-3. [DOI] [PubMed] [Google Scholar]
- Shangold M., Freeman R., Thysen B., Gatz M. The relationship between long-distance running, plasma progesterone, and luteal phase length. Fertil Steril. 1979 Feb;31(2):130–133. doi: 10.1016/s0015-0282(16)43811-2. [DOI] [PubMed] [Google Scholar]
- Stenchever M. A., Parks K. J., Daines T. L., Allen M. A., Stenchever M. R. Cytogenetics of habitual abortion and other reproductive wastage. Am J Obstet Gynecol. 1977 Jan 15;127(2):143–150. doi: 10.1016/s0002-9378(16)33240-9. [DOI] [PubMed] [Google Scholar]
- Stray-Pedersen B., Stray-Pedersen S. Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion. Am J Obstet Gynecol. 1984 Jan 15;148(2):140–146. doi: 10.1016/s0002-9378(84)80164-7. [DOI] [PubMed] [Google Scholar]
- Sørensen S. S. Minor müllerian anomalies and oligomenorrhea in infertile women. A new syndrome. Am J Obstet Gynecol. 1981 Jul 15;140(6):636–644. doi: 10.1016/0002-9378(81)90196-4. [DOI] [PubMed] [Google Scholar]
- Taylor P. J., Cumming D. C., Hill P. J. Significance of intrauterine adhesions detected hysteroscopically in eumenorrheic infertile women and role of antecedent curettage in their formation. Am J Obstet Gynecol. 1981 Feb 1;139(3):239–242. doi: 10.1016/0002-9378(81)90001-6. [DOI] [PubMed] [Google Scholar]
- Tharapel A. T., Tharapel S. A., Bannerman R. M. Recurrent pregnancy losses and parental chromosome abnormalities: a review. Br J Obstet Gynaecol. 1985 Sep;92(9):899–914. doi: 10.1111/j.1471-0528.1985.tb03069.x. [DOI] [PubMed] [Google Scholar]
- Tulandi T., Arronet G. H., McInnes R. A. Arcuate and bicornuate uterine anomalies and infertility. Fertil Steril. 1980 Oct;34(4):362–364. doi: 10.1016/s0015-0282(16)45023-5. [DOI] [PubMed] [Google Scholar]
- Tulandi T., Arronet G. H., McInnes R. A. Infertility in women over the age of 36. Fertil Steril. 1981 Jun;35(6):611–614. doi: 10.1016/s0015-0282(16)45550-0. [DOI] [PubMed] [Google Scholar]
- Ward B. E., Henry G. P., Robinson A. Cytogenetic studies in 100 couples with recurrent spontaneous abortions. Am J Hum Genet. 1980 Jul;32(4):549–554. [PMC free article] [PubMed] [Google Scholar]
