Abstract
Three genetically distinct groups of treponemes have been identified by saturation reassociation assays using 125I-labeled treponemal DNAs. The three groups are (i) virulent Treponema pallidum (Nichols strain), (ii) T. phagedenis and its biotypes Reiter and Kazan 5, and (iii) T. refringens biotypes Nichols and Noguchi. There is no detectable DNA sequence homology (less than 5%) among the three groups. The groups have distinct guanine + cytosine contents: 52.4 to 53.7% for T. pallidum, 41.5% for T. refringens, and 38 to 39% for T. phagedenis.
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Selected References
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- Baseman J. B., Nichols J. C., Rumpp J. W., Hayes N. S. Purification of Treponema pallidum from Infected Rabbit Tissue: Resolution into Two Treponemal Populations. Infect Immun. 1974 Nov;10(5):1062–1067. doi: 10.1128/iai.10.5.1062-1067.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chacko C. W. Accidental human infection in the laboratory with Nichols rabbit-adapted virulent strain of Treponema pallidum. Bull World Health Organ. 1966;35(5):809–810. [PMC free article] [PubMed] [Google Scholar]
- DEACON W. E., HUNTER E. F. Treponemal antigens as related to identification and syphilis serology. Proc Soc Exp Biol Med. 1962 Jun;110:352–356. doi: 10.3181/00379727-110-27515. [DOI] [PubMed] [Google Scholar]
- DULBECCO R., VOGT M. Plaque formation and isolation of pure lines with poliomyelitis viruses. J Exp Med. 1954 Feb;99(2):167–182. doi: 10.1084/jem.99.2.167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fieldsteel A. H., Becker F. A., Stout J. G. Prolonged survival of virulent Treponema pallidum (Nichols strain) in cell-free and tissue culture systems. Infect Immun. 1977 Oct;18(1):173–182. doi: 10.1128/iai.18.1.173-182.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fitzgerald J. J., Johnson R. C., Smith M. Accidental laboratory infection with Treponema pallidum, Nichols strain. J Am Vener Dis Assoc. 1976 Dec;3(2 Pt 1):76–78. [PubMed] [Google Scholar]
- HANSON A. W., CANNEFAX G. R. RECOVERY OF TREPONEMA AND BORRELIA AFTER LYOPHILIZATION. J Bacteriol. 1964 Sep;88:811–811. doi: 10.1128/jb.88.3.811-811.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUDSON E. H. TREPONEMATOSIS AND AFRICAN SLAVERY. Br J Vener Dis. 1964 Mar;40:43–52. doi: 10.1136/sti.40.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUNTER E. F., DEACON W. E., MEYER P. E. AN IMPROVED FTA TEST FOR SYPHILIS, THE ABSORPTION PROCEDURE (FTA-ABS). Public Health Rep. 1964 May;79:410–412. [PMC free article] [PubMed] [Google Scholar]
- Hardy P. H., Jr, Nell E. E. Isolation and purification of Treponema pallidum from syphilitic lesions in rabbits. Infect Immun. 1975 Jun;11(6):1296–1299. doi: 10.1128/iai.11.6.1296-1299.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miao R., Dougherty R. M. Characterization of human papovavirus RFV: comparison with SV40 and BKV. J Gen Virol. 1977 Apr;35(1):67–75. doi: 10.1099/0022-1317-35-1-67. [DOI] [PubMed] [Google Scholar]
- REITER H. An account of the so-called Reiter treponeme (history, isolation, cultivation, specificity, and utilization). Br J Vener Dis. 1960 Mar;36:18–20. doi: 10.1136/sti.36.1.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wilkinson A. E., Johnston N. A. A comparison between sorbent and Reiter sonicate in the absorbed fluorescent treponemal antibody test. Ann N Y Acad Sci. 1975 Jun 30;254:395–399. doi: 10.1111/j.1749-6632.1975.tb29190.x. [DOI] [PubMed] [Google Scholar]
- Willcox R. R. Changing patterns of treponemal disease. Br J Vener Dis. 1974 Jun;50(3):169–178. doi: 10.1136/sti.50.3.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willcox R. R., Guthe T. Treponema pallidum. A bibliographical review of the morphology, culture and survival of T. pallidum and associated organisms. Bull World Health Organ. 1966;35:1–169. [PMC free article] [PubMed] [Google Scholar]