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. 1978 Feb;133(2):472–476. doi: 10.1128/jb.133.2.472-476.1978

Effect of cerulenin on Streptococcus faecalis macromolecular synthesis and cell division.

D Carson, L Daneo-Moore
PMCID: PMC222047  PMID: 415039

Abstract

The antibiotic cerulenin has been used to study macromolecular synthesis and cell division in Streptococcus faecalis. The data suggest that lipid and lipoteichoic acid synthesis as well as cell number increase are affected prior to any observable effects on overall mass increase or DNA, RNA, protein, or peptidoglycan synthesis. Treatment with cerulenin of cultures growing at various rates and analysis of the subsequent cell divisions indicate that the antibiotic may block a cell cycle event that precedes the completion of chromosome replication by about 10 min.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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