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. 1978 Feb;133(2):744–754. doi: 10.1128/jb.133.2.744-754.1978

Cluster of genes controlling proline degradation in Salmonella typhimurium.

B Ratzkin, J Roth
PMCID: PMC222083  PMID: 342507

Abstract

A cluster of genes essential for degradation of proline to glutamate (put) is located between the pyrC and pyrD loci at min 22 of the Salmonella chromosome. A series of 25 deletion mutants of this region have been isolated and used to construct a fine-structure map of the put genes. The map includes mutations affecting the proline degradative activities, proline oxidase and pyrroline-5-carboxylic dehydrogenase. Also included are mutations affecting the major proline permease and a regulatory mutation that affects both enzyme and permease production. The two enzymatic activities appear to be encoded by a single gene (putA). The regulatory mutation maps between the putA gene and the proline permease gene (putP).

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Selected References

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