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. 1997;75(1):76–78. doi: 10.1038/bjc.1997.12

Ca125 and neuron-specific enolase (NSE) as tumour markers for intra-abdominal desmoplastic small round-cell tumours.

K Fizazi 1, F Farhat 1, C Theodore 1, O Rixe 1, A Le Cesne 1, E Comoy 1, T Le Chevalier 1
PMCID: PMC2222692  PMID: 9000601

Abstract

Seven consecutive patients with intra-abdominal desmoplastic small round-cell tumours were screened at presentation for carcinoembryonic antigen (CEA), Ca19-9, Ca15-3, Ca125, alpha-fetoprotein (AFP), human chorionic gonadotrophin (hCG) and neuron-specific enolase (NSE). Initially elevated tumour markers were used to monitor therapy and follow-up. Tumour marker assays were all in the normal range, with the exception of Ca125 and NSE. The Ca125 level was initially high in six of the seven patients (86%) with a median value of 200 U ml-1 and a range of 22-735 U ml-1. The NSE value was elevated before therapy in three of the five patients (60%) for whom assay results were available, with a median of 19 ng ml-1 and a range of 6.8-37.5 ng ml-1 . Ca1 25 normalized in five out of six cases and NSE always normalized during chemotherapy, but neither of these two tumour markers correlated specifically with response, as only one patient experienced a partial response, five tumour stabilization and the remaining patient tumour progression. At progression, Ca125 was again elevated in two out of four cases several weeks before clinical relapse and NSE in only one out of three cases. Ca125 and NSE are frequently raised in the serum of patients with intra-abdominal desmoplastic small round-cell tumours before therapy, but are not reliable monitors of the course of the disease. However, normalization is frequently associated with an improvement of symptoms or a moderate clinical response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arriagada R., Le Chevalier T., Pignon J. P., Rivière A., Monnet I., Chomy P., Tuchais C., Tarayre M., Ruffié P. Initial chemotherapeutic doses and survival in patients with limited small-cell lung cancer. N Engl J Med. 1993 Dec 16;329(25):1848–1852. doi: 10.1056/NEJM199312163292504. [DOI] [PubMed] [Google Scholar]
  2. Bast R. C., Jr, Klug T. L., St John E., Jenison E., Niloff J. M., Lazarus H., Berkowitz R. S., Leavitt T., Griffiths C. T., Parker L. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 1983 Oct 13;309(15):883–887. doi: 10.1056/NEJM198310133091503. [DOI] [PubMed] [Google Scholar]
  3. Bergmann J. F., Bidart J. M., George M., Beaugrand M., Levy V. G., Bohuon C. Elevation of CA 125 in patients with benign and malignant ascites. Cancer. 1987 Jan 15;59(2):213–217. doi: 10.1002/1097-0142(19870115)59:2<213::aid-cncr2820590206>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  4. Carney D. N., Marangos P. J., Ihde D. C., Bunn P. A., Jr, Cohen M. H., Minna J. D., Gazdar A. F. Serum neuron-specific enolase: a marker for disease extent and response to therapy of small-cell lung cancer. Lancet. 1982 Mar 13;1(8272):583–585. doi: 10.1016/s0140-6736(82)91748-2. [DOI] [PubMed] [Google Scholar]
  5. Diez M., Cerdàn F. J., Ortega M. D., Torres A., Picardo A., Balibrea J. L. Evaluation of serum CA 125 as a tumor marker in non-small cell lung cancer. Cancer. 1991 Jan 1;67(1):150–154. doi: 10.1002/1097-0142(19910101)67:1<150::aid-cncr2820670126>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  6. Farhat F., Culine S., Lhomme C., Duvillard P., Terrier-Lacombe M. J., Michel G., Soulie P., Theodore C., Lotz J. P., Droz J. P. Tumeurs desmoplastiques à petites cellules rondes de l'adulte: une nouvelle entité. Bull Cancer. 1995 Aug;82(8):665–673. [PubMed] [Google Scholar]
  7. Fisken J., Leonard R. C., Stewart M., Beattie G. J., Sturgeon C., Aspinall L., Roulston J. E. The prognostic value of early CA125 serum assay in epithelial ovarian carcinoma. Br J Cancer. 1993 Jul;68(1):140–145. doi: 10.1038/bjc.1993.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Frappaz D., Bouffet E., Dolbeau D., Bouvier R., Carrie C., Louis D., Pondarre C., Tabone E., Philip T., Brunat-Mentigny M. Desmoplastic small round cell tumors of the abdomen. Cancer. 1994 Mar 15;73(6):1753–1756. doi: 10.1002/1097-0142(19940315)73:6<1753::aid-cncr2820730633>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  9. Gerald W. L., Miller H. K., Battifora H., Miettinen M., Silva E. G., Rosai J. Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol. 1991 Jun;15(6):499–513. [PubMed] [Google Scholar]
  10. Gerald W. L., Rosai J. Case 2. Desmoplastic small cell tumor with divergent differentiation. Pediatr Pathol. 1989;9(2):177–183. doi: 10.3109/15513818909022347. [DOI] [PubMed] [Google Scholar]
  11. Gerald W. L., Rosai J. Desmoplastic small cell tumor with multi-phenotypic differentiation. Zentralbl Pathol. 1993 Jun;139(2):141–151. [PubMed] [Google Scholar]
  12. Gonzalez-Crussi F., Crawford S. E., Sun C. C. Intraabdominal desmoplastic small-cell tumors with divergent differentiation. Observations on three cases of childhood. Am J Surg Pathol. 1990 Jul;14(7):633–642. doi: 10.1097/00000478-199007000-00004. [DOI] [PubMed] [Google Scholar]
  13. Johnson P. W., Joel S. P., Love S., Butcher M., Pandian M. R., Squires L., Wrigley P. F., Slevin M. L. Tumour markers for prediction of survival and monitoring of remission in small cell lung cancer. Br J Cancer. 1993 Apr;67(4):760–766. doi: 10.1038/bjc.1993.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Ladanyi M., Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res. 1994 Jun 1;54(11):2837–2840. [PubMed] [Google Scholar]
  15. Nõu E., Steinholtz L., Bergh J., Nilsson K., Påhlman S. Neuron-specific enolase as a follow-up marker in small cell bronchial carcinoma. A prospective study in an unselected series. Cancer. 1990 Mar 15;65(6):1380–1385. doi: 10.1002/1097-0142(19900315)65:6<1380::aid-cncr2820650622>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  16. Ordóez N. G., Zirkin R., Bloom R. E. Malignant small-cell epithelial tumor of the peritoneum coexpressing mesenchymal-type intermediate filaments. Am J Surg Pathol. 1989 May;13(5):413–421. doi: 10.1097/00000478-198905000-00009. [DOI] [PubMed] [Google Scholar]
  17. Ordóez N. G., el-Naggar A. K., Ro J. Y., Silva E. G., Mackay B. Intra-abdominal desmoplastic small cell tumor: a light microscopic, immunocytochemical, ultrastructural, and flow cytometric study. Hum Pathol. 1993 Aug;24(8):850–865. doi: 10.1016/0046-8177(93)90135-4. [DOI] [PubMed] [Google Scholar]
  18. Prinz R. A., Marangos P. J. Use of neuron-specific enolase as a serum marker for neuroendocrine neoplasms. Surgery. 1982 Nov;92(5):887–889. [PubMed] [Google Scholar]
  19. Variend S., Gerrard M., Norris P. D., Goepel J. R. Intra-abdominal neuroectodermal tumour of childhood with divergent differentiation. Histopathology. 1991 Jan;18(1):45–51. doi: 10.1111/j.1365-2559.1991.tb00813.x. [DOI] [PubMed] [Google Scholar]
  20. Zeltzer P. M., Marangos P. J., Parma A. M., Sather H., Dalton A., Hammond D., Siegel S. E., Seeger R. C. Raised neuron-specific enolase in serum of children with metastatic neuroblastoma. A report from the Children's Cancer Study Group. Lancet. 1983 Aug 13;2(8346):361–363. doi: 10.1016/s0140-6736(83)90342-2. [DOI] [PubMed] [Google Scholar]
  21. van Zandwijk N., Jassem E., Bonfrer J. M., van Tinteren H. Value of neuron specific enolase in early detection of relapse in small cell lung carcinoma. Eur J Cancer. 1990 Mar;26(3):373–376. doi: 10.1016/0277-5379(90)90236-m. [DOI] [PubMed] [Google Scholar]

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