Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1997;75(8):1213–1216. doi: 10.1038/bjc.1997.207

Hepatic arterial cannulation for regional chemotherapy is safe in patients with a liver metastasis volume of less than 1 litre.

D Burke 1, C Fordy 1, S A Earlam 1, T G Allen-Mersh 1
PMCID: PMC2222792  PMID: 9099972

Abstract

Hepatic arterial cannulation for regional chemotherapy was achieved in 121/134 (90.2%) of colorectal liver metastasis patients. The perioperative mortality (5.8%) was significantly greater (P = 0.004) in patients with > 1000 ml (5/22, 23%) compared with < 1000 ml (2/83, 2.4%) metastasis volume. Colorectal liver metastasis patients should be considered for regional chemotherapy before metastases become extensive.

Full text

PDF
1213

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen-Mersh T. G., Earlam S., Fordy C., Abrams K., Houghton J. Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal liver metastases. Lancet. 1994 Nov 5;344(8932):1255–1260. doi: 10.1016/s0140-6736(94)90750-1. [DOI] [PubMed] [Google Scholar]
  2. Allen-Mersh T. G. Improving survival after large bowel cancer. BMJ. 1991 Sep 14;303(6803):595–596. doi: 10.1136/bmj.303.6803.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burke D., Earlam S., Fordy C., Allen-Mersh T. G. Effect of aberrant hepatic arterial anatomy on tumour response to hepatic artery infusion of floxuridine for colorectal liver metastases. Br J Surg. 1995 Aug;82(8):1098–1100. doi: 10.1002/bjs.1800820830. [DOI] [PubMed] [Google Scholar]
  4. Campbell K. A., Burns R. C., Sitzmann J. V., Lipsett P. A., Grochow L. B., Niederhuber J. E. Regional chemotherapy devices: effect of experience and anatomy on complications. J Clin Oncol. 1993 May;11(5):822–826. doi: 10.1200/JCO.1993.11.5.822. [DOI] [PubMed] [Google Scholar]
  5. Chang A. E., Schneider P. D., Sugarbaker P. H., Simpson C., Culnane M., Steinberg S. M. A prospective randomized trial of regional versus systemic continuous 5-fluorodeoxyuridine chemotherapy in the treatment of colorectal liver metastases. Ann Surg. 1987 Dec;206(6):685–693. doi: 10.1097/00000658-198712000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cohen A. M., Kaufman S. D., Wood W. C., Greenfield A. J. Regional hepatic chemotherapy using an implantable drug infusion pump. Am J Surg. 1983 Apr;145(4):529–533. doi: 10.1016/0002-9610(83)90053-3. [DOI] [PubMed] [Google Scholar]
  7. Curley S. A., Chase J. L., Roh M. S., Hohn D. C. Technical considerations and complications associated with the placement of 180 implantable hepatic arterial infusion devices. Surgery. 1993 Nov;114(5):928–935. [PubMed] [Google Scholar]
  8. Dunn D. L. Gram-negative bacterial sepsis and sepsis syndrome. Surg Clin North Am. 1994 Jun;74(3):621–635. [PubMed] [Google Scholar]
  9. Dworkin M. J., Allen-Mersh T. G. Regional infusion chemotherapy for colorectal hepatic metastases--where is it going? Cancer Treat Rev. 1991 Dec;18(4):213–224. doi: 10.1016/0305-7372(91)90013-p. [DOI] [PubMed] [Google Scholar]
  10. Dworkin M. J., Burke D., Earlam S., Fordy C., Allen-Mersh T. G. Measurement of response to treatment in colorectal liver metastases. Br J Cancer. 1995 Apr;71(4):873–876. doi: 10.1038/bjc.1995.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Dworkin M. J., Earlam S., Fordy C., Allen-Mersh T. G. Importance of hepatic artery node involvement in patients with colorectal liver metastases. J Clin Pathol. 1995 Mar;48(3):270–272. doi: 10.1136/jcp.48.3.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jenkins P. J., Williams R. Fulminant viral hepatitis. Clin Gastroenterol. 1980 Jan;9(1):171–189. [PubMed] [Google Scholar]
  13. Martin J. K., Jr, O'Connell M. J., Wieand H. S., Fitzgibbons R. J., Jr, Mailliard J. A., Rubin J., Nagorney D. M., Tschetter L. K., Krook J. E. Intra-arterial floxuridine vs systemic fluorouracil for hepatic metastases from colorectal cancer. A randomized trial. Arch Surg. 1990 Aug;125(8):1022–1027. doi: 10.1001/archsurg.1990.01410200086013. [DOI] [PubMed] [Google Scholar]
  14. Meta-Analysis Group in Cancer. Piedbois P., Buyse M., Kemeny N., Rougier P., Carlson R., Allen-Mersh T., O'Connell M., Chang A., Sondak V. Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. J Natl Cancer Inst. 1996 Mar 6;88(5):252–258. doi: 10.1093/jnci/88.5.252. [DOI] [PubMed] [Google Scholar]
  15. Steele G., Jr, Ravikumar T. S. Resection of hepatic metastases from colorectal cancer. Biologic perspective. Ann Surg. 1989 Aug;210(2):127–138. doi: 10.1097/00000658-198908000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ueda T., Shimada E., Urakawa T. Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis. J Gastroenterol. 1994 Aug;29(4):423–429. doi: 10.1007/BF02361238. [DOI] [PubMed] [Google Scholar]
  17. de Haes J. C., van Knippenberg F. C., Neijt J. P. Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer. 1990 Dec;62(6):1034–1038. doi: 10.1038/bjc.1990.434. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES