Abstract
Selective inhibition of growth by pentitols was observed when Klebsiella aerogenes M-7 which could not utilize pentitols was grown on pentoses. D-Arabitol inhibited the growth on D-arabinose as a sole carbon source, but had no effect on the growth on L-arabinose, D-xylose, and D-ribose. Similarly, L-arabitol inhibited the growth on D-arabinose and L-arabinose, ribitol inhibited the growth on D-arabinose and L-arabinose, and xylitol inhibited the growth on D-xylose. From the following reasons, we postulated that the selective growth inhibition by pentitols was due to the competitive inhibition of pentose isomerase reaction by the cell by pentitols. (i) D-Arabinose transport activity was not inhibited by pentitols. (ii) Induction of D-arabinose and L-arabinose isomerases was not inhibited by D- and L-arabitol, respectively. (iii) The specificity of growth inhibition by pentitols was the same as that of competitive inhibition of pentose isomerases by pentitols.
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- CHAKRAVORTY M. INDUCTION AND REPRESSION OF L-ARABINOSE ISOMERASE IN LACTOBACILLUS PLANTARUM. Biochim Biophys Acta. 1964 Apr 6;85:152–161. doi: 10.1016/0926-6569(64)90175-0. [DOI] [PubMed] [Google Scholar]
- DOBROGOSZ W. J., DEMOSS R. D. INDUCTION AND REPRESSION OF L-ARABINOSE ISOMERASE IN PEDIOCOCCUS PENTOSACEUS. J Bacteriol. 1963 Jun;85:1350–1355. doi: 10.1128/jb.85.6.1350-1355.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HULLEY S. B., JORGENSEN S. B., LIN E. C. Ribitol dehydrogenase in Aerobacter aerogenes 1033. Biochim Biophys Acta. 1963 Feb 12;67:219–225. doi: 10.1016/0006-3002(63)91819-5. [DOI] [PubMed] [Google Scholar]
- Hill A. V. The Combinations of Haemoglobin with Oxygen and with Carbon Monoxide. I. Biochem J. 1913 Oct;7(5):471–480. doi: 10.1042/bj0070471. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORTLOCK R. P., WOOD W. A. METABOLISM OF PENTOSES AND PENTITOLS BY AEROBACTER AEROGENES. I. DEMONSTRATION OF PENTOSE ISOMERASE, PENTULOKINASE, AND PENTITOL DEHYDROGENASE ENZYME FAMILIES. J Bacteriol. 1964 Oct;88:838–844. doi: 10.1128/jb.88.4.838-844.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakamatu T., Yamanaka K. Crystallization and properties of L-arabinose isomerase from Lactobacillus gayonii. Biochim Biophys Acta. 1969 Mar 18;178(1):156–165. doi: 10.1016/0005-2744(69)90142-9. [DOI] [PubMed] [Google Scholar]
- Patrick J. W., Lee N. Purification and properties of an L-arabinose isomerase from Escherichia coli. J Biol Chem. 1968 Aug 25;243(16):4312–4318. [PubMed] [Google Scholar]
- Reiner A. M. Xylitol and D-arabitol toxicities due to derepressed fructose, galactitol, and sorbitol phosphotransferases of Escherichia coli. J Bacteriol. 1977 Oct;132(1):166–173. doi: 10.1128/jb.132.1.166-173.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yamanaka K. Purification, crystallization and properties of the D-xylose isomerase from Lactobacillus brevis. Biochim Biophys Acta. 1968 Mar 25;151(3):670–680. doi: 10.1016/0005-2744(68)90015-6. [DOI] [PubMed] [Google Scholar]