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. 1997;75(10):1543–1546. doi: 10.1038/bjc.1997.263

Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas.

J Piffkò 1, A Bànkfalvi 1, D Ofner 1, M Bryne 1, D Rasch 1, U Joos 1, W Böcker 1, K W Schmid 1
PMCID: PMC2223514  PMID: 9166951

Abstract

Tumour cells at the invasive front of carcinomas have been found to differ substantially from the rest of tumour cells in a variety of human cancers. The present multivariate survival analysis of 94 oral squamous cell carcinomas (OSCCs) revealed that both the argyrophilic nucleolar organizer regions-associated protein (AgNOR) content of invading tumour cells and a multiparametric histopathological tumour front grade were significantly and independently associated with tumour-related death, irrespective of conventional Broders' grade and clinical stage of the tumours. High tumour front scores and AgNOR content at the invasive OSCC front thus seem to reflect increased malignant potential. Proliferative activity, assessed by standardized AgNOR analysis, most probably represents one of the biological features underlying the usefulness of evaluating the invasive tumour front.

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Selected References

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  1. Barasch A., Morse D. E., Krutchkoff D. J., Eisenberg E. Smoking, gender, and age as risk factors for site-specific intraoral squamous cell carcinoma. A case-series analysis. Cancer. 1994 Feb 1;73(3):509–513. doi: 10.1002/1097-0142(19940201)73:3<509::aid-cncr2820730303>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  2. Bryne M., Jenssen N., Boysen M. Histological grading in the deep invasive front of T1 and T2 glottic squamous cell carcinomas has high prognostic value. Virchows Arch. 1995;427(3):277–281. doi: 10.1007/BF00203395. [DOI] [PubMed] [Google Scholar]
  3. Bryne M., Koppang H. S., Lilleng R., Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992 Apr;166(4):375–381. doi: 10.1002/path.1711660409. [DOI] [PubMed] [Google Scholar]
  4. Bryne M., Koppang H. S., Lilleng R., Stene T., Bang G., Dabelsteen E. New malignancy grading is a better prognostic indicator than Broders' grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989 Sep;18(8):432–437. doi: 10.1111/j.1600-0714.1989.tb01339.x. [DOI] [PubMed] [Google Scholar]
  5. Derenzini M., Trerè D. AgNOR proteins as a parameter of the rapidity of cell proliferation. Zentralbl Pathol. 1994 Mar;140(1):7–10. [PubMed] [Google Scholar]
  6. Fielding L. P., Fenoglio-Preiser C. M., Freedman L. S. The future of prognostic factors in outcome prediction for patients with cancer. Cancer. 1992 Nov 1;70(9):2367–2377. doi: 10.1002/1097-0142(19921101)70:9<2367::aid-cncr2820700927>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  7. Janot F., Klijanienko J., Russo A., Mamet J. P., de Braud F., El-Naggar A. K., Pignon J. P., Luboinski B., Cvitkovic E. Prognostic value of clinicopathological parameters in head and neck squamous cell carcinoma: a prospective analysis. Br J Cancer. 1996 Feb;73(4):531–538. doi: 10.1038/bjc.1996.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Jones A. S. Prognosis in mouth cancer: tumour factors. Eur J Cancer B Oral Oncol. 1994 Jan;30B(1):8–15. doi: 10.1016/0964-1955(94)90044-2. [DOI] [PubMed] [Google Scholar]
  9. Ofner D., Bankfalvi A., Riehemann K., Bier B., Böcker W., Schmid K. W. Wet autoclave pretreatment improves the visualization of silver-stained nucleolar organizer-region-associated proteins in routinely formalin-fixed and paraffin-embedded tissues. Mod Pathol. 1994 Dec;7(9):946–950. [PubMed] [Google Scholar]
  10. Ofner D., Bier B., Heinrichs S., Berghorn M., Dünser M., Hagemann H. A., Langer D., Böcker W., Schmid K. W. Demonstration of silver-stained nucleolar organizer region associated proteins (AgNORs) after wet autoclave pretreatment in breast carcinoma: correlation to tumor stage and long-term survival. Breast Cancer Res Treat. 1996;39(2):165–176. doi: 10.1007/BF01806183. [DOI] [PubMed] [Google Scholar]
  11. Ofner D., Hittmair A., Marth C., Ofner C., Tötsch M., Daxenbichler G., Mikuz G., Margreiter R., Schmid K. W. Relationship between quantity of silver stained nucleolar organizer regions associated proteins (Ag-NORs) and population doubling time in ten breast cancer cell lines. Pathol Res Pract. 1992 Aug;188(6):742–746. doi: 10.1016/S0344-0338(11)80171-8. [DOI] [PubMed] [Google Scholar]
  12. Ofner D., Riedmann B., Maier H., Hittmair A., Rumer A., Tötsch M., Spechtenhauser B., Böcker W., Schmid K. W. Standardized staining and analysis of argyrophilic nucleolar organizer region associated proteins (AgNORs) in radically resected colorectal adenocarcinoma--correlation with tumour stage and long-term survival. J Pathol. 1995 Apr;175(4):441–448. doi: 10.1002/path.1711750412. [DOI] [PubMed] [Google Scholar]
  13. Roland N. J., Caslin A. W., Nash J., Stell P. M. Value of grading squamous cell carcinoma of the head and neck. Head Neck. 1992 May-Jun;14(3):224–229. doi: 10.1002/hed.2880140310. [DOI] [PubMed] [Google Scholar]
  14. Teixeira C. R., Tanaka S., Haruma K., Yoshihara M., Sumii K., Kajiyama G. Proliferating cell nuclear antigen expression at the invasive tumor margin predicts malignant potential of colorectal carcinomas. Cancer. 1994 Feb 1;73(3):575–579. doi: 10.1002/1097-0142(19940201)73:3<575::aid-cncr2820730313>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  15. Trerè D., Pession A., Derenzini M. The silver-stained proteins of interphasic nucleolar organizer regions as a parameter of cell duplication rate. Exp Cell Res. 1989 Sep;184(1):131–137. doi: 10.1016/0014-4827(89)90371-6. [DOI] [PubMed] [Google Scholar]
  16. Verhoeven D., Bourgeois N., Derde M. P., Kaufman L., Buyssens N. Comparison of cell growth in different parts of breast cancers. Histopathology. 1990 Dec;17(6):505–509. doi: 10.1111/j.1365-2559.1990.tb00789.x. [DOI] [PubMed] [Google Scholar]
  17. Weir J. C., Davenport W. D., Skinner R. L. A diagnostic and epidemiologic survey of 15,783 oral lesions. J Am Dent Assoc. 1987 Sep;115(3):439–442. doi: 10.14219/jada.archive.1987.0248. [DOI] [PubMed] [Google Scholar]
  18. Welkoborsky H. J., Hinni M., Dienes H. P., Mann W. J. Predicting recurrence and survival in patients with laryngeal cancer by means of DNA cytometry, tumor front grading, and proliferation markers. Ann Otol Rhinol Laryngol. 1995 Jul;104(7):503–510. doi: 10.1177/000348949510400701. [DOI] [PubMed] [Google Scholar]
  19. Woolgar J. A., Scott J. Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue/floor of mouth. Head Neck. 1995 Nov-Dec;17(6):463–472. doi: 10.1002/hed.2880170603. [DOI] [PubMed] [Google Scholar]

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