Skip to main content
British Journal of Cancer logoLink to British Journal of Cancer
. 1997;76(1):52–53. doi: 10.1038/bjc.1997.335

Expression of high-affinity 67-kDa laminin receptors in primary breast cancers and metachronous metastatic lesions or contralateral cancers.

M G Daidone 1, R Silvestrini 1, E Benini 1, W F Grigioni 1, A D'Errico 1
PMCID: PMC2223804  PMID: 9218732

Abstract

The presence of high-affinity 67-kDa laminin receptors, detected immunohistochemically, was determined on 63 primary breast cancers and on metachronous metastatic lesions or contralateral cancers from the same patients. A disagreement was observed in two-thirds of the cases. In particular, laminin receptor content was significantly lower (P = 0.02) in local recurrences and slightly higher in lymph node metastasis than in the corresponding primary tumours.

Full text

PDF
52

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Castronovo V. Laminin receptors and laminin-binding proteins during tumor invasion and metastasis. Invasion Metastasis. 1993;13(1):1–30. [PubMed] [Google Scholar]
  2. Daidone M. G., Silvestrini R., D'Errico A., Di Fronzo G., Benini E., Mancini A. M., Garbisa S., Liotta L. A., Grigioni W. F. Laminin receptors, collagenase IV and prognosis in node-negative breast cancers. Int J Cancer. 1991 Jun 19;48(4):529–532. doi: 10.1002/ijc.2910480409. [DOI] [PubMed] [Google Scholar]
  3. Hunt G. The role of laminin in cancer invasion and metastasis. Exp Cell Biol. 1989;57(3):165–176. doi: 10.1159/000163521. [DOI] [PubMed] [Google Scholar]
  4. Liotta L. A. Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res. 1986 Jan;46(1):1–7. [PubMed] [Google Scholar]
  5. Marques L. A., Franco E. L., Torloni H., Brentani M. M., da Silva-Neto J. B., Brentani R. R. Independent prognostic value of laminin receptor expression in breast cancer survival. Cancer Res. 1990 Mar 1;50(5):1479–1483. [PubMed] [Google Scholar]
  6. Martignone S., Ménard S., Bufalino R., Cascinelli N., Pellegrini R., Tagliabue E., Andreola S., Rilke F., Colnaghi M. I. Prognostic significance of the 67-kilodalton laminin receptor expression in human breast carcinomas. J Natl Cancer Inst. 1993 Mar 3;85(5):398–402. doi: 10.1093/jnci/85.5.398. [DOI] [PubMed] [Google Scholar]
  7. Silvestrini R., Valentinis B., Daidone M. G., Di Fronzo G., Coradini D., Salvadori B. Biological characterisation of primary and metachronous lesions in breast cancer patients. Eur J Cancer. 1992;28A(12):2006–2010. doi: 10.1016/0959-8049(92)90249-2. [DOI] [PubMed] [Google Scholar]
  8. Wewer U. M., Liotta L. A., Jaye M., Ricca G. A., Drohan W. N., Claysmith A. P., Rao C. N., Wirth P., Coligan J. E., Albrechtsen R. Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin. Proc Natl Acad Sci U S A. 1986 Oct;83(19):7137–7141. doi: 10.1073/pnas.83.19.7137. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES