Abstract
It was shown experimentally that ACTH causes an increase of cytoplasmic RNA and subcellular granules of the adrenal cortex shortly after administration. This effect was found to be concentrated primarily on the basophilic cytoplasmic granules and to be largely independent of cell division. The increase of nuclear RNA, DNA, and nuclear mass followed that of the cytoplasm. The observations indicate also that the mass increase of mitochondrial and chromidial systems is closely related to the increase in cytoplasmic, largely chromidial RNA.
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Selected References
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- FIALA S., SPROUL E. E., BLUTINGER M. E., FIALA A. E. Basophilic chromidia and mitochondria in normal and in tumor tissue. J Histochem Cytochem. 1955 May;3(3):212–226. doi: 10.1177/3.3.212. [DOI] [PubMed] [Google Scholar]
- LAIRD A. K., NYGAARD O., RIS H., BARTON A. D. Separation of mitochondria into two morphologically and biochemically distinct types. Exp Cell Res. 1953 Sep;5(1):147–160. doi: 10.1016/0014-4827(53)90100-1. [DOI] [PubMed] [Google Scholar]
- PALADE G. E. A small particulate component of the cytoplasm. J Biophys Biochem Cytol. 1955 Jan;1(1):59–68. doi: 10.1083/jcb.1.1.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PALADE G. E., PORTER K. R. Studies on the endoplasmic reticulum. I. Its identification in cells in situ. J Exp Med. 1954 Dec 1;100(6):641–656. doi: 10.1084/jem.100.6.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PORTER K. R. Electron microscopy of basophilic components of cytoplasm. J Histochem Cytochem. 1954 Sep;2(5):346–375. doi: 10.1177/2.5.346. [DOI] [PubMed] [Google Scholar]
- SCHNEIDER W. C. Biochemical constitution of mammalian mitochondria. J Histochem Cytochem. 1953 Jul;1(4):212–233. doi: 10.1177/1.4.212. [DOI] [PubMed] [Google Scholar]
- THOMSON R. Y., HEAGY F. C., HUTCHISON W. C., DAVIDSON J. N. The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue. Biochem J. 1953 Feb;53(3):460–474. doi: 10.1042/bj0530460. [DOI] [PMC free article] [PubMed] [Google Scholar]