THE EFFECTS OF FLUORIDE FEEDING ON THE ORGANIC MATRIX OF BONES AND TEETH OF PIGS AS OBSERVED BY AUTORADIOGRAPHY AFTER IN VITRO UPTAKE OF CA⁴⁵ AND S³⁵

Abstract

Demineralized sections of fluorinated bones and teeth have been studied by autoradiography following in vitro uptake of Ca⁴⁵ or S³⁵O₄. The portions of tissue which do not become mineralized (cartilage, prebone, predentine, and precementum) show an increased Ca⁴⁵ uptake apparently related to an increase in chondroitin sulfate content in fluorosis. The tissues from the fluoride-fed animals show an increase of in vitro uptake of sulfur in the tissues which become mineralized (bone, dentine, cementum).

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