Abstract
Preliminary results of an electron microscope study of a leukemia of the mouse transmissible by cell-free filtrates are reported. In twelve out of forty-seven specimens examined, virus-like particles were observed. So far, these particles have not been observed in control, non-leukemic animals. They are located inside the cytoplasm of leukemic cells which infiltrate the spleen or the liver. Their diameter is approximately 78 mµ. Their resemblance to other particles recently described in different mouse tumors is stressed. Their significance and, in correlation with ultrafiltration data, their possible etiological meaning are discussed.
Full Text
The Full Text of this article is available as a PDF (1.6 MB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAMS W. R., PRINCE A. M. An electron microscope study of the morphology and distribution of the intracytoplasmic virus-like particles of Ehrlich ascites tumor cells. J Biophys Biochem Cytol. 1957 Mar 25;3(2):161–170. doi: 10.1083/jcb.3.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BERNHARD W., BAUER A., GUERIN M., OBERLING C. Etude au microscope électronique de corpuscules d'aspect virusal dans des épithéliomas mammaires de la souris. Bull Assoc Fr Etud Cancer. 1955;42(2):163–178. [PubMed] [Google Scholar]
- FAWCETT D. W. Electron microscope observations on intracellular virus-like particles associated with the cells of the Lucké renal adenocarcinoma. J Biophys Biochem Cytol. 1956 Nov 25;2(6):725–741. doi: 10.1083/jcb.2.6.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRIEDLAENDER M., MOORE D. H., LOVE R., BROWN R. A., KOPROWSKI H. Studies with the electron microscope of virus-host relationships in Ehrlich ascites tumor cells. I. The identification and structure of anopheles A virus. J Exp Med. 1955 Oct 1;102(4):361–370. doi: 10.1084/jem.102.4.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRIEDLAENDER M., MOORE D. H. Occurrence of bodies within endoplasmic reticulum of Ehrlich ascites tumor cells. Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):828–831. doi: 10.3181/00379727-92-22627. [DOI] [PubMed] [Google Scholar]
- FRIEND C. Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia. J Exp Med. 1957 Apr 1;105(4):307–318. doi: 10.1084/jem.105.4.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GAYLORD W. H., Jr Virus-like particles associated with the Rous sarcoma as seen in sections of tumor. Cancer Res. 1955 Feb;15(2):80–83. [PubMed] [Google Scholar]
- HAGUENAU F., BERNHARD W. L'appareil de Golgi dans les cellules normales et cancéreuses de vertébrés; rappel historique et étude au microscope électronique. Arch Anat Microsc Morphol Exp. 1955;44(1):27–55. [PubMed] [Google Scholar]
- MOORE D. H., GRIMLEY P. H. Problems in methacrylate embedding for electron microscopy. J Biophys Biochem Cytol. 1957 Mar 25;3(2):255–260. doi: 10.1083/jcb.3.2.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORGAN C., GODMAN G. C., ROSE H. M., HOWE C., HUANG J. S. Electron microscopic and histochemical studies of an unusual crystalline protein occurring in cells infected by type 5 adenovirus. J Biophys Biochem Cytol. 1957 May 25;3(3):505–508. doi: 10.1083/jcb.3.3.505. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORGAN C., ROSE H. M., MOORE D. H. Structure and development of viruses observed in the electron microscope. III. Influenza virus. J Exp Med. 1956 Aug 1;104(2):171–182. doi: 10.1084/jem.104.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SELBY C. C., GREY C. E., LICHTENBERG S., FRIEND C., MOORE A. E., BIESELE J. J. Submicroscopic cytoplasmic particles occasionally found in the Ehrlich mouse ascites tumor. Cancer Res. 1954 Dec;14(11):790–794. [PubMed] [Google Scholar]