Abstract
The structure of the rat parietal cell was examined by electron microscopy. The intercellular and intracellular canalculi are lined by microvilli which are more numerous and larger than those of other gastric cells. The numerous mitochondria have closely packed cristae and a dense matrix containing opaque particles. The cytoplasmic vacuoles typical of parietal cells are part of a network of smooth surfaced tubules and vacuoles (the endoplasmic reticulum) which is intimately associated with the mitochondria and probably connected with the lumen of the canaliculi. Only a few dense particles are found attached to the surface of these tubules. The structure of the parietal cell is compared with that of other cells whose function also is transport of inorganic ions and water. Evidence is presented supporting the hypothesis that parietal cells differentiate from a less structurally specialized cell in the neck region of the gastric gland.
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Selected References
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- CHALLICE C. E., BULLIVANT S., SCOTT D. B. The fine structure of some cytoplasmic inclusions of oxyntic cells. Exp Cell Res. 1957 Dec;13(3):488–492. doi: 10.1016/0014-4827(57)90077-0. [DOI] [PubMed] [Google Scholar]
- DALTON A. J. Electron micrography of epithelial cells of the gastro-intestinal tract and pancreas. Am J Anat. 1951 Jul;89(1):109–133. doi: 10.1002/aja.1000890105. [DOI] [PubMed] [Google Scholar]
- HALLY A. D. Functional changes in the vacuole-containing bodies of the gastric parietal cell. Nature. 1959 Feb 7;183(4658):408–408. doi: 10.1038/183408a0. [DOI] [PubMed] [Google Scholar]
- HALLY A. D. The fine structure of the gastric parietal cell in the mouse. J Anat. 1959 Apr;93(2):217–225. [PMC free article] [PubMed] [Google Scholar]
- Hughes W. L., Bond V. P., Brecher G., Cronkite E. P., Painter R. B., Quastler H., Sherman F. G. CELLULAR PROLIFERATION IN THE MOUSE AS REVEALED BY AUTORADIOGRAPHY WITH TRITIATED THYMIDINE. Proc Natl Acad Sci U S A. 1958 May;44(5):476–483. doi: 10.1073/pnas.44.5.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEBLOND C. P., WALKER B. E. Renewal of cell populations. Physiol Rev. 1956 Apr;36(2):255–276. doi: 10.1152/physrev.1956.36.2.255. [DOI] [PubMed] [Google Scholar]
- ODLAND G. F. The fine structure of the interrelationship of cells in the human epidermis. J Biophys Biochem Cytol. 1958 Sep 25;4(5):529–538. [PMC free article] [PubMed] [Google Scholar]
- PALADE G. E. A study of fixation for electron microscopy. J Exp Med. 1952 Mar;95(3):285–298. doi: 10.1084/jem.95.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PALADE G. E., SIEKEVITZ P. Liver microsomes; an integrated morphological and biochemical study. J Biophys Biochem Cytol. 1956 Mar 25;2(2):171–200. doi: 10.1083/jcb.2.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PEASE D. C. Infolded basal plasma membranes found in epithelia noted for their water transport. J Biophys Biochem Cytol. 1956 Jul 25;2(4 Suppl):203–208. doi: 10.1083/jcb.2.4.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RHODIN J., DALHAMN T. Electron microscopy of the tracheal ciliated mucosa in rat. Z Zellforsch Mikrosk Anat. 1956;44(4):345–412. doi: 10.1007/BF00345847. [DOI] [PubMed] [Google Scholar]
- WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol. 1958 Jul 25;4(4):475–478. doi: 10.1083/jcb.4.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEISS J. M. Mitochondrial changes induced by potassium and sodium in the duodenal absorptive cell as studied with the electron microscope. J Exp Med. 1955 Dec 1;102(6):783–788. doi: 10.1084/jem.102.6.783. [DOI] [PMC free article] [PubMed] [Google Scholar]