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. 1978 Sep;135(3):1167–1170. doi: 10.1128/jb.135.3.1167-1170.1978

Effects of antipain (a protease inhibitor) on respiration, viability, and excision of pyrimidine dimers in UV-irradiated Escherichia coli cells.

P A Swenson, R L Schenley
PMCID: PMC222500  PMID: 211114

Abstract

The protease inhibitor antipain increases the effectiveness of UV irradiation on cessation of respiration and cell killing in Escherichia coli B/r cultures without affecting excision of pyrimidine dimers. The actions are similar to those caused by cyclic AMP in irradiated cultures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Meyn M. S., Rossman T., Troll W. A protease inhibitor blocks SOS functions in Escherichia coli: antipain prevents lambda repressor inactivation, ultraviolet mutagenesis, and filamentous growth. Proc Natl Acad Sci U S A. 1977 Mar;74(3):1152–1156. doi: 10.1073/pnas.74.3.1152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Roberts J. W., Roberts C. W., Mount D. W. Inactivation and proteolytic cleavage of phage lambda repressor in vitro in an ATP-dependent reaction. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2283–2287. doi: 10.1073/pnas.74.6.2283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Schenley R. L., Fisher W. D., Swenson P. A., Khachatourians G. G. Centrifugal separation of irradiated cultures of Escherichia coli cells into viable and nonviable populations. J Bacteriol. 1976 May;126(2):977–984. doi: 10.1128/jb.126.2.977-984.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Swenson P. A., Joshi J. G., Schenley R. L. Regulation of cessation of respiration and killing by cyclic 3',5'-adenosine monophosphate and its receptor protein after far-ultraviolet irradiation of Escherichia coli. Mol Gen Genet. 1978 Feb 16;159(2):125–130. doi: 10.1007/BF00270885. [DOI] [PubMed] [Google Scholar]
  5. Swenson P. A., Schenley R. L. Evidence relating cessation of respiration, cell envelope changes, and death in ultraviolet-irradiated Escherichia coli B-r cells. J Bacteriol. 1974 Feb;117(2):551–559. doi: 10.1128/jb.117.2.551-559.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Swenson P. A., Schenley R. L., Joshi J. G. Role of cyclic adenosine 3',5'-monophosphate on cessation of respiration in ultraviolet-irradiated Escherichia coli. J Bacteriol. 1977 Aug;131(2):707–709. doi: 10.1128/jb.131.2.707-709.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Swenson P. A., Schenley R. L. Respiration, growth and viability of repair-deficient mutants of Escherichia coli after ultraviolet irradiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1974 Jan;25(1):51–60. doi: 10.1080/09553007414550051. [DOI] [PubMed] [Google Scholar]
  8. Umezawa S., Tatsuta K., Fujimoto K., Tsuchiya T., Umezawa H. Structure of antipain, a new Sakaguchi-positive product of streptomyces. J Antibiot (Tokyo) 1972 Apr;25(4):267–270. doi: 10.7164/antibiotics.25.267. [DOI] [PubMed] [Google Scholar]
  9. Witkin E. M. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriol Rev. 1976 Dec;40(4):869–907. doi: 10.1128/br.40.4.869-907.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]

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