Abstract
An electron microscopic survey has been made of the gastric parietal or oxyntic cell of the human, cat, beaver, dog, hamster, rat, mouse, and bat, and of the corresponding cell type in two species of frog, two species of toad, and the horned lizard. A feature consistently found in the parietal cells of the mammals or their equivalent in the lower vertebrates is the agranular endoplasmic reticulum, which takes the form of branching and anastomosing small tubules approximately 200 to 500 A in diameter, sometimes expanded into flattened cisternae. In mammalian parietal cells this form of the endoplasmic reticulum is found only in limited amounts, but in the corresponding secretory cells of the amphibia and reptilia the tubular agranular reticulum is abundant. It is believed to comprise a more or less continuous system of channels, but owing to their tortuous course only short profiles are seen in thin sections. Immediately subjacent to the plasmalemma at the free surface, the cytoplasm is relatively free of organelles but is occasionally traversed by the agranular reticulum, which appears to be continuous at some points with the cell surface. The possible participation of the agranular endoplasmic reticulum in hydrochloric acid secretion is discussed.
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- BENNETT H. S., LUFT J. H. zeta-Collidine as a basis for buffering fixatives. J Biophys Biochem Cytol. 1959 Aug;6(1):113–114. doi: 10.1083/jcb.6.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BRADFORD N. M., DAVIES R. E. The site of hydrochloric acid production in the stomach as determined by indicators. Biochem J. 1950 Apr;46(4):414–420. doi: 10.1042/bj0460414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHALLICE C. E., BULLIVANT S., SCOTT D. B. The fine structure of some cytoplasmic inclusions of oxyntic cells. Exp Cell Res. 1957 Dec;13(3):488–492. doi: 10.1016/0014-4827(57)90077-0. [DOI] [PubMed] [Google Scholar]
- CHRISTENSEN A. K., FAWCETT D. W. The normal fine structure of opossum testicular interstitial cells. J Biophys Biochem Cytol. 1961 Mar;9:653–670. doi: 10.1083/jcb.9.3.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CURRAN P. F. Na, Cl, and water transport by rat ileum in vitro. J Gen Physiol. 1960 Jul;43:1137–1148. doi: 10.1085/jgp.43.6.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DALTON A. J. Electron micrography of epithelial cells of the gastro-intestinal tract and pancreas. Am J Anat. 1951 Jul;89(1):109–133. doi: 10.1002/aja.1000890105. [DOI] [PubMed] [Google Scholar]
- DAVIES R. E. The metabolism of the acidsecreting stomach. Am J Dig Dis. 1959 Mar;4(3):173–183. doi: 10.1007/BF02231221. [DOI] [PubMed] [Google Scholar]
- HALLY A. D. The fine structure of the gastric parietal cell in the mouse. J Anat. 1959 Apr;93(2):217–225. [PMC free article] [PubMed] [Google Scholar]
- HELANDER H., EKHOLM R. Ultrastructure of epithelial cells in the fundus glands of the mouse gastric mucosa. J Ultrastruct Res. 1959 Oct;3:74–83. doi: 10.1016/s0022-5320(59)80017-4. [DOI] [PubMed] [Google Scholar]
- LAWN A. M. Observations on the fine structure of the gastric parietal cell of the rat. J Biophys Biochem Cytol. 1960 Feb;7:161–166. doi: 10.1083/jcb.7.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PALAY S. L., KARLIN L. J. An electron microscopic study of the intestinal villus. I. The fasting animal. J Biophys Biochem Cytol. 1959 May 25;5(3):363–372. doi: 10.1083/jcb.5.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VIAL J. D., ORREGO H. Electron microscope observations on the fine structure of parietal cells. J Biophys Biochem Cytol. 1960 Apr;7:367–372. doi: 10.1083/jcb.7.2.367. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. II. Application of solutions containing lead and barium. J Biophys Biochem Cytol. 1958 Nov 25;4(6):727–730. doi: 10.1083/jcb.4.6.727. [DOI] [PMC free article] [PubMed] [Google Scholar]