Table 4.

Duration of REM Sleep and Number of REM Bouts Observed Per Hour Following Treatment with MDL100907, RO4368554, Zolpidem, and Vehicle

ZT	Vehicle	MDL100907, mg/kg			RO4368554, mg/kg			Zolpidem, mg/kg
		0.3	1.0	3.0	1.0	3.0	10.0	10.0
REM Bout Duration
19	0.32 ± 0.16	0.06 ± 0.06	0.19 ± 0.10	0.02 ± 0.02	0.28 ± 0.21	0.06 ± 0.06	0.30 ± 0.16	0.18 ± 0.08
20	0.67 ± 0.16	0.96 ± 0.24b	1.06 ± 0.24b	0.47 ± 0.19	0.71 ± 0.20b	0.90 ± 0.16b	0.83 ± 0.19b	0.13 ± 0.10a
21	0.83 ± 0.20	1.36 ± 0.20ab	1.40 ± 0.25ab	0.80 ± 0.22b	0.56 ± 0.18	0.83 ± 0.16	0.77 ± 0.16	0.42 ± 0.09
22	0.94 ± 0.18	0.96 ± 0.22b	0.80 ± 0.20	1.00 ± 0.28b	0.53 ± 0.15	0.57 ± 0.24	0.87 ± 0.18	0.53 ± 0.14
23	0.25 ± 0.08	0.64 ± 0.26b	0.92 ± 0.31ab	0.69 ± 0.15b	0.21 ± 0.14	0.44 ± 0.21	0.24 ± 0.14	0.16 ± 0.11
24	0.32 ± 0.20	0.33 ± 0.21	0.47 ± 0.24	0.54 ± 0.31b	0.07 ± 0.04	0.04 ± 0.04	0.19 ± 0.10	0.02 ± 0.02
Number of REM Bouts
19	0.44 ± 0.24	0.11 ± 0.11	0.33 ± 0.17	0.11 ± 0.11	0.22 ± 0.15	0.22 ± 0.22	0.56 ± 0.34	0.78 ± 0.36
20	2.22 ± 0.70	1.22 ± 0.28	1.33 ± 0.29	1.22 ± 0.55	2.44 ± 0.69	2.78 ± 0.70	2.11 ± 0.56	0.56 ± 0.44
21	2.78 ± 0.66	3.22 ± 0.62	2.78 ± 0.78	1.89 ± 0.56	2.78 ± 0.83	3.67 ± 0.73	2.89 ± 0.79	2.22 ± 0.46
22	3.56 ± 1.25	2.89 ± 0.79	3.11 ± 0.86	2.00 ± 0.50	2.33 ± 0.78	1.44 ± 0.50	3.89 ± 1.12	1.89 ± 0.65
23	1.44 ± 0.85	1.33 ± 0.55	1.11 ± 0.48	2.56 ± 0.69	0.67 ± 0.37	0.78 ± 0.32	1.44 ± 0.82	0.44 ± 0.34
24	0.44 ± 0.24	0.44 ± 0.24	0.78 ± 0.36	1.11 ± 0.51	0.44 ± 0.24	0.56 ± 0.56	0.44 ± 0.24	0.11 ± 0.11

Data are expressed as mean ± SEM duration of rapid eye movement sleep (REM), in minutes, and mean number (± SEM) of bouts of REM. ZT refers to Zeitgeber time.

^aDifferent from vehicle P < 0.05

^bDifferent from zolpidem P < 0.05