Abstract
Temperature increases cause a regular and reproducible increase in the frequency of generation of pacemaker potentials in most Aplysia neurons specialized for this type of activity which can only be explained as a direct stimulating effect of temperature upon the ionic mechanisms responsible for pacemaker potentials. At the same time all cells in the visceral ganglion undergo a membrane potential hyperpolarization of approximately 1–2 mv/°C warmed. In spite of the marked variation in resting membrane potential the critical firing threshold remains at a constant membrane potential level at all temperatures in the absence of accommodative changes. The temperature-frequency curves of all types of cells are interpreted as a result of the interaction between the effects of temperature on the pacemaker-generating mechanism and resting membrane potential. Previous observations on the effects of temperature on excitability of mammalian neurons suggest that other types of neurons may undergo similar marked shifts in resting membrane potential with temperature variation.
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Selected References
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- AXELSSON J., BULBRING E. Metabolic factors affecting the electrical activity of intestinal smooth muscle. J Physiol. 1961 Apr;156:344–356. doi: 10.1113/jphysiol.1961.sp006680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CORABOEUF E., WEIDMANN S. Temperature effects on the electrical activity of Purkinje fibres. Helv Physiol Pharmacol Acta. 1954;12(1):32–41. [PubMed] [Google Scholar]
- HODGKIN A. L., KATZ B. The effect of temperature on the electrical activity of the giant axon of the squid. J Physiol. 1949 Aug;109(1-2):240–249. doi: 10.1113/jphysiol.1949.sp004388. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KERKUT G. A., TAYLOR B. J. Effect of temperature on the spontaneous activity from the isolated ganglia of the slug, cockroach and crayfish. Nature. 1956 Aug 25;178(4530):426–426. doi: 10.1038/178426a0. [DOI] [PubMed] [Google Scholar]
- KERKUT G. A., THOMAS R. C. AN ELECTROGENIC SODIUM PUMP IN SNAIL NERVE CELLS. Comp Biochem Physiol. 1965 Jan;14:167–183. doi: 10.1016/0010-406x(65)90017-4. [DOI] [PubMed] [Google Scholar]
- LING G., WOODBURY J. W. Effect of temperature on the membrane potential of frog muscle fibers. J Cell Physiol. 1949 Dec;34(3):407–412. doi: 10.1002/jcp.1030340306. [DOI] [PubMed] [Google Scholar]
- LIPPOLD O. C., NICHOLLS J. G., REDFEARN J. W. A study of the afferent discharge produced by cooling a mammalian muscle spindle. J Physiol. 1960 Sep;153:218–231. doi: 10.1113/jphysiol.1960.sp006530. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Murray R. W. The effect of temperature on the membrane properties of neurons in the visceral ganglion of Aplysia. Comp Biochem Physiol. 1966 Jun;18(2):291–303. doi: 10.1016/0010-406x(66)90188-5. [DOI] [PubMed] [Google Scholar]
- SUDA I., KOIZUMI K., BROOKS C. M. Analysis of effects of hypothermia on central nervous system responses. Am J Physiol. 1957 May;189(2):373–380. doi: 10.1152/ajplegacy.1957.189.2.373. [DOI] [PubMed] [Google Scholar]
- TAUC L. [Diversity of the modes of activity of the nerve cells of the disconnected ganglion of Aplysia]. C R Seances Soc Biol Fil. 1960;154:17–21. [PubMed] [Google Scholar]