Abstract
Structural information is presented for three muscle systems—mammalian smooth muscle at rest and partially active, living toad striated muscle at rest and contracting, and glycerinated rabbit psoas muscle under various conditions of pH and ionic environment. In the smooth muscle no evidence of organized myosin filaments has been found. In the striated muscle the myosin-to-actin distance can vary widely, according to sarcomere length and to muscle treatment, both at rest and during contraction. In the discussion it is suggested that muscle should be considered as a colloidal system and that there need not necessarily be any chemical bonding (cross-linking) involved in the contractile process.
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Selected References
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- Elliott G. F., Lowy J., Millman B. M. Low-angle x-ray diffraction studies of living striated muscle during contraction. J Mol Biol. 1967 Apr 14;25(1):31–45. doi: 10.1016/0022-2836(67)90277-x. [DOI] [PubMed] [Google Scholar]
- Elliott G. F., Lowy J., Millman B. M. X-ray diffraction from living striated muscle during contraction. Nature. 1965 Jun 26;206(991):1357–1358. doi: 10.1038/2061357a0. [DOI] [PubMed] [Google Scholar]
- HUXLEY A. F., NIEDERGERKE R. Structural changes in muscle during contraction; interference microscopy of living muscle fibres. Nature. 1954 May 22;173(4412):971–973. doi: 10.1038/173971a0. [DOI] [PubMed] [Google Scholar]
- HUXLEY H. E. The double array of filaments in cross-striated muscle. J Biophys Biochem Cytol. 1957 Sep 25;3(5):631–648. doi: 10.1083/jcb.3.5.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUXLEY H., HANSON J. Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation. Nature. 1954 May 22;173(4412):973–976. doi: 10.1038/173973a0. [DOI] [PubMed] [Google Scholar]
- Hanson J., Lowy J. Molecular basis of contractility in muscle. Br Med Bull. 1965 Sep;21(3):264–271. doi: 10.1093/oxfordjournals.bmb.a070407. [DOI] [PubMed] [Google Scholar]
- Huxley H. E., Brown W., Holmes K. C. Constancy of axial spacings in frog sartorius muscle during contraction. Nature. 1965 Jun 26;206(991):1358–1358. doi: 10.1038/2061358a0. [DOI] [PubMed] [Google Scholar]
- Millman B. M., Elliott G. F. X-ray diffraction from contracting molluscan muscle. Nature. 1965 May 22;206(4986):824–825. doi: 10.1038/206824a0. [DOI] [PubMed] [Google Scholar]
- Reedy M. K., Holmes K. C., Tregear R. T. Induced changes in orientation of the cross-bridges of glycerinated insect flight muscle. Nature. 1965 Sep 18;207(5003):1276–1280. doi: 10.1038/2071276a0. [DOI] [PubMed] [Google Scholar]
- WORTHINGTON C. R. X-ray diffraction studies on the large-scale molecular structure of insect muscle. J Mol Biol. 1961 Oct;3:618–633. doi: 10.1016/s0022-2836(61)80025-9. [DOI] [PubMed] [Google Scholar]