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. 1969 Oct 1;54(4):437–461. doi: 10.1085/jgp.54.4.437

Ionic Permeability of the Inhibitory Postsynaptic Membrane of Lobster Muscle Fibers

Fumiaki Motokizawa 1, John P Reuben 1, Harry Grundfest 1
PMCID: PMC2225941  PMID: 4309874

Abstract

Reversal potentials (E IPSP) of the inhibitory postsynaptic potential and the membrane resting potentials (EM) of lobster muscle fibers were determined with intracellular recording under a variety of ionic conditions. E IPSP is solely dependent on the electromotive force of anionic batteries; i.e., on the electrochemical gradient for a "mobile" fraction of intracellular Cl (Cli) which is considerably smaller than the total intracellular Cl. The active inhibitory membrane is more permeable to certain "foreign" anions in the order NO3 > SCN > Br > Cl. The membrane is impermeable to BrOs, isethionate, and methylsulfate, but is slightly permeable to acetate and propionate. The level of Cli appears to be determined in part by some active (pump?) process and most of the anions studied appear to interfere with the steady-state level of Cli.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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