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. 1970 Dec 1;56(6):673–691. doi: 10.1085/jgp.56.6.673

Characteristics of the Amino Acid Transport System in the Mucosal Border of Rabbit Ileum

Jean Jacques Hajjar 1, Peter F Curran 1
PMCID: PMC2225979  PMID: 5483101

Abstract

The specificity of the neutral amino acid transport system in the brush border was examined by studying the ability of amino acid analogues to inhibit the unidirectional influx of phenylalanine from mucosal solution into the cells. Effects were evaluated in terms of the affinity of various substrates for the amino acid site in the transport system. The affinity of amino acids for the site was proportional to the number of carbon atoms in the side chain. Electron-withdrawing substituents in the ring of phenylalanine increased affinity and electron-releasing groups decreased affinity. Removal of the α-amino group from phenylalanine decreased affinity by a factor of approximately 50 and removal of the carboxyl group decreased affinity 12-fold. Effects on affinity of variations in the side chain of the amino acid can be comparable in magnitude to that of the carboxyl group. The effect of sodium ion on the transport system appears to be similar for all compounds tested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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