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. 1973 Sep 1;62(3):255–270. doi: 10.1085/jgp.62.3.255

Nerve-Muscle Interaction In Vitro

Role of acetylcholine

J H Steinbach 1, AJ Harris 1, J Patrick 1, D Schubert 1, S Heinemann 1
PMCID: PMC2226117  PMID: 4738329

Abstract

Nerve and muscle cells from clonal lines interact in vitro, resulting in the association on the muscle surface of an area of increased acetylcholine sensitivity with a site of nerve-muscle contact. This localization of acetylcholine sensitivity on the muscle cell to a site of contact between nerve and muscle was found to occur when acetylcholine receptors on the muscle had been blocked with α-neurotoxin. Localization was also found to occur when the nerve cell had been prevented from releasing acetylcholine. It is concluded that neither the presence of active acetylcholine receptors on the muscle, nor the release of acetylcholine from the nerve, was required for the events leading to the localization of acetylcholine sensitivity in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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