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. 1997;76(5):675–677. doi: 10.1038/bjc.1997.444

Aspirin and colorectal cancer.

C La Vecchia 1, E Negri 1, S Franceschi 1, E Conti 1, M Montella 1, A Giacosa 1, A Falcini 1, A Decarli 1
PMCID: PMC2228005  PMID: 9303370

Abstract

The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and selected dietary factors.

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Selected References

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  1. Franceschi S., Negri E., Salvini S., Decarli A., Ferraroni M., Filiberti R., Giacosa A., Talamini R., Nanni O., Panarello G. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items. Eur J Cancer. 1993;29A(16):2298–2305. doi: 10.1016/0959-8049(93)90225-5. [DOI] [PubMed] [Google Scholar]
  2. Gann P. H., Manson J. E., Glynn R. J., Buring J. E., Hennekens C. H. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst. 1993 Aug 4;85(15):1220–1224. doi: 10.1093/jnci/85.15.1220. [DOI] [PubMed] [Google Scholar]
  3. Giovannucci E., Egan K. M., Hunter D. J., Stampfer M. J., Colditz G. A., Willett W. C., Speizer F. E. Aspirin and the risk of colorectal cancer in women. N Engl J Med. 1995 Sep 7;333(10):609–614. doi: 10.1056/NEJM199509073331001. [DOI] [PubMed] [Google Scholar]
  4. Giovannucci E., Rimm E. B., Stampfer M. J., Colditz G. A., Ascherio A., Willett W. C. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med. 1994 Aug 15;121(4):241–246. doi: 10.7326/0003-4819-121-4-199408150-00001. [DOI] [PubMed] [Google Scholar]
  5. Greenberg E. R., Baron J. A. Aspirin and other nonsteroid anti-inflammatory drugs as cancer-preventive agents. IARC Sci Publ. 1996;(139):91–98. [PubMed] [Google Scholar]
  6. Kelly J. P., Rosenberg L., Kaufman D. W., Shapiro S. Reliability of personal interview data in a hospital-based case-control study. Am J Epidemiol. 1990 Jan;131(1):79–90. doi: 10.1093/oxfordjournals.aje.a115488. [DOI] [PubMed] [Google Scholar]
  7. Kune G. A., Kune S., Watson L. F. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 1988 Aug 1;48(15):4399–4404. [PubMed] [Google Scholar]
  8. Levi F., Lucchini F., La Vecchia C. Worldwide patterns of cancer mortality, 1985-89. Eur J Cancer Prev. 1994 Mar;3(2):109–143. doi: 10.1097/00008469-199403000-00004. [DOI] [PubMed] [Google Scholar]
  9. Muscat J. E., Stellman S. D., Wynder E. L. Nonsteroidal antiinflammatory drugs and colorectal cancer. Cancer. 1994 Oct 1;74(7):1847–1854. doi: 10.1002/1097-0142(19941001)74:7<1847::aid-cncr2820740704>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  10. Paganini-Hill A. Aspirin and the prevention of colorectal cancer: a review of the evidence. Semin Surg Oncol. 1994 May-Jun;10(3):158–164. doi: 10.1002/ssu.2980100303. [DOI] [PubMed] [Google Scholar]
  11. Paganini-Hill A., Chao A., Ross R. K., Henderson B. E. Aspirin use and chronic diseases: a cohort study of the elderly. BMJ. 1989 Nov 18;299(6710):1247–1250. doi: 10.1136/bmj.299.6710.1247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Paganini-Hill A., Ross R. K. Reliability of recall of drug usage and other health-related information. Am J Epidemiol. 1982 Jul;116(1):114–122. doi: 10.1093/oxfordjournals.aje.a113386. [DOI] [PubMed] [Google Scholar]
  13. Peleg I. I., Maibach H. T., Brown S. H., Wilcox C. M. Aspirin and nonsteroidal anti-inflammatory drug use and the risk of subsequent colorectal cancer. Arch Intern Med. 1994 Feb 28;154(4):394–399. [PubMed] [Google Scholar]
  14. Rosenberg L., Palmer J. R., Zauber A. G., Warshauer M. E., Stolley P. D., Shapiro S. A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer. J Natl Cancer Inst. 1991 Mar 6;83(5):355–358. doi: 10.1093/jnci/83.5.355. [DOI] [PubMed] [Google Scholar]
  15. Schreinemachers D. M., Everson R. B. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology. 1994 Mar;5(2):138–146. doi: 10.1097/00001648-199403000-00003. [DOI] [PubMed] [Google Scholar]
  16. Suh O., Mettlin C., Petrelli N. J. Aspirin use, cancer, and polyps of the large bowel. Cancer. 1993 Aug 15;72(4):1171–1177. doi: 10.1002/1097-0142(19930815)72:4<1171::aid-cncr2820720407>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  17. Thun M. J., Namboodiri M. M., Calle E. E., Flanders W. D., Heath C. W., Jr Aspirin use and risk of fatal cancer. Cancer Res. 1993 Mar 15;53(6):1322–1327. [PubMed] [Google Scholar]
  18. Thun M. J., Namboodiri M. M., Heath C. W., Jr Aspirin use and reduced risk of fatal colon cancer. N Engl J Med. 1991 Dec 5;325(23):1593–1596. doi: 10.1056/NEJM199112053252301. [DOI] [PubMed] [Google Scholar]

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