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. 1997;76(6):784–787. doi: 10.1038/bjc.1997.462

Classical gene amplifications in human breast cancer are not associated with distant solid metastases.

K Driouch 1, M H Champème 1, M Beuzelin 1, I Bièche 1, R Lidereau 1
PMCID: PMC2228028  PMID: 9310246

Abstract

To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression.

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Selected References

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