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. 1997;76(7):890–893. doi: 10.1038/bjc.1997.480

Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.

D Fink 1, S Nebel 1, S Aebi 1, H Zheng 1, H K Kim 1, R D Christen 1, S B Howell 1
PMCID: PMC2228055  PMID: 9328148

Abstract

hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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