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. 1997;76(8):983–991. doi: 10.1038/bjc.1997.497

Deletion mapping and linkage analysis provide strong indication for the involvement of the human chromosome region 8p12-p22 in breast carcinogenesis.

S Seitz 1, K Rohde 1, E Bender 1, A Nothnagel 1, H Pidde 1, O M Ullrich 1, A El-Zehairy 1, W Haensch 1, B Jandrig 1, K Kölble 1, P M Schlag 1, S Scherneck 1
PMCID: PMC2228086  PMID: 9376278

Abstract

We have identified a high frequency of loss of heterozygosity (LOH) on the human chromosome region 8p12-p22 in a panel of microdissected familial (86% LOH) and sporadic (74% LOH) breast tumours. The two most frequently deleted regions were defined around marker D8S133 and in a broader centromeric region bounded by markers D8S137 and D8S339. We cannot unequivocally characterize the 8p12-p22 loss as an early or a late event in breast carcinogenesis. In parallel, we have performed linkage analysis in four German breast cancer families. A location score greater than 13.67 corresponding to a LOD score of 2.97 at the marker D8S137 has been obtained. Our results considerably strengthen the evidence for a breast cancer susceptibility gene(s) located on the short arm of the chromosome region at 8p12-p22.

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Selected References

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