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British Journal of Cancer logoLink to British Journal of Cancer
. 1997;76(9):1181–1183. doi: 10.1038/bjc.1997.530

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

J van Asperen 1, O van Tellingen 1, A Sparreboom 1, A H Schinkel 1, P Borst 1, W J Nooijen 1, J H Beijnen 1
PMCID: PMC2228133  PMID: 9365166

Abstract

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.

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Selected References

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