Skip to main content
NCBI home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1997;75(9):1291–1294. doi: 10.1038/bjc.1997.219

The Rhesus D-negative phenotype is an independent predictor of poor prognosis in curatively (RO) resected gastric cancer patients.

B Mayer 1, W Schraut 1, I Funke 1, K W Jauch 1, W Mempel 1, J P Johnson 1, F W Schildberg 1
PMCID: PMC2228249  PMID: 9155048

Abstract

Among gastric cancer patients, the Rhesus D-negative phenotype correlated with increased tumour recurrence [all patients, n = 83, P = 0.026; curatively (R0) resected patients, n = 51, P = 0.093] and reduced overall survival time (all patients, log-rank P = 0.0028; R0 patients, log-rank P = 0.0003) and was identified in multivariate analysis as the most important independent prognostic marker in the R0 patient group (relative risk 9.1, P = 0.0013).

Full text

PDF
1291

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryne M., Eide G. E., Lilleng R., Langmark F., Thrane P. S., Dabelsteen E. A multivariate study of the prognosis of oral squamous cell carcinomas. Are blood group and hemoglobin new prognostic factors? Cancer. 1991 Nov 1;68(9):1994–1998. doi: 10.1002/1097-0142(19911101)68:9<1994::aid-cncr2820680925>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  2. Bryne M., Thrane P. S., Lilleng R., Dabelsteen E. Prognostic value of Rhesus blood groups in oral squamous cell carcinomas. Cancer. 1991 Nov 15;68(10):2213–2216. doi: 10.1002/1097-0142(19911115)68:10<2213::aid-cncr2820681020>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  3. Cerny T., Blair V., Anderson H., Bramwell V., Thatcher N. Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients. Int J Cancer. 1987 Feb 15;39(2):146–149. doi: 10.1002/ijc.2910390204. [DOI] [PubMed] [Google Scholar]
  4. Cerny T., Fey M. F., Oppliger R., Castiglione M., Nachbur B., Gertsch M., Gasser A., Joss R. A., Thatcher N., Lind M. Prevalence of the Rhesus-negative phenotype in Caucasian patients with small-cell lung cancer (SCLC). Int J Cancer. 1992 Sep 30;52(3):504–506. doi: 10.1002/ijc.2910520328. [DOI] [PubMed] [Google Scholar]
  5. Chérif-Zahar B., Mattéi M. G., Le Van Kim C., Bailly P., Cartron J. P., Colin Y. Localization of the human Rh blood group gene structure to chromosome region 1p34.3-1p36.1 by in situ hybridization. Hum Genet. 1991 Feb;86(4):398–400. doi: 10.1007/BF00201843. [DOI] [PubMed] [Google Scholar]
  6. Ezaki T., Yanagisawa A., Ohta K., Aiso S., Watanabe M., Hibi T., Kato Y., Nakajima T., Ariyama T., Inazawa J. Deletion mapping on chromosome 1p in well-differentiated gastric cancer. Br J Cancer. 1996 Feb;73(4):424–428. doi: 10.1038/bjc.1996.76. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hyland C. A., Wolter L. C., Saul A. Three unrelated Rh D gene polymorphisms identified among blood donors with Rhesus CCee (r'r') phenotypes. Blood. 1994 Jul 1;84(1):321–324. [PubMed] [Google Scholar]
  8. Jauch K. W., Heiss M. M., Gruetzner U., Funke I., Pantel K., Babic R., Eissner H. J., Riethmueller G., Schildberg F. W. Prognostic significance of bone marrow micrometastases in patients with gastric cancer. J Clin Oncol. 1996 Jun;14(6):1810–1817. doi: 10.1200/JCO.1996.14.6.1810. [DOI] [PubMed] [Google Scholar]
  9. Kvist E., Krogh J., Hjortberg P. Prognostic variables in patients with prostate cancer: influence of blood group ABO (H), the Rhesus system, age, differentiation, tumour stage and metastases. Int Urol Nephrol. 1992;24(4):417–423. doi: 10.1007/BF02550636. [DOI] [PubMed] [Google Scholar]
  10. Kvist E., Krogh J., Rye B. Blood groups and urothelial tumours of the upper urinary tract. A study of 295 patients. Scand J Urol Nephrol. 1990;24(4):253–255. [PubMed] [Google Scholar]
  11. Maehara Y., Oshiro T., Baba H., Ohno S., Kohnoe S., Sugimachi K. Lymphatic invasion and potential for tumor growth and metastasis in patients with gastric cancer. Surgery. 1995 Apr;117(4):380–385. doi: 10.1016/s0039-6060(05)80056-x. [DOI] [PubMed] [Google Scholar]
  12. Roder J. D., Böttcher K., Siewert J. R., Busch R., Hermanek P., Meyer H. J. Prognostic factors in gastric carcinoma. Results of the German Gastric Carcinoma Study 1992. Cancer. 1993 Oct 1;72(7):2089–2097. doi: 10.1002/1097-0142(19931001)72:7<2089::aid-cncr2820720706>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  13. Sano T., Tsujino T., Yoshida K., Nakayama H., Haruma K., Ito H., Nakamura Y., Kajiyama G., Tahara E. Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas. Cancer Res. 1991 Jun 1;51(11):2926–2931. [PubMed] [Google Scholar]
  14. Slater G., Itzkowitz S., Azar S., Aufses A. H., Jr Clinicopathologic correlations of ABO and Rhesus blood type in colorectal cancer. Dis Colon Rectum. 1993 Jan;36(1):5–7. doi: 10.1007/BF02050293. [DOI] [PubMed] [Google Scholar]
  15. Tahara E. Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis. Cancer. 1995 Mar 15;75(6 Suppl):1410–1417. doi: 10.1002/1097-0142(19950315)75:6+<1410::aid-cncr2820751504>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  16. Telen M. J. Erythrocyte blood group antigens: not so simple after all. Blood. 1995 Jan 15;85(2):299–306. [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES