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. 1969 Nov;64(3):857–862. doi: 10.1073/pnas.64.3.857

MITOTIC ABNORMALITIES IN SEA URCHIN EMBRYOS EXPOSED TO DACTINOMYCIN*

Barry I Kiefer 1, Charles F Entelis 1, Anthony A Infante 1
PMCID: PMC223313  PMID: 4905991

Abstract

Dactinomycin at concentrations of 10, 20, 25, and 50 μg/ml causes mitotic abnormalities in sea urchin embryos. Sister chromosome separation is impaired and anaphase bridges are frequently formed. The result is an unequal distribution of the chromosome complement to daughter cells. Possible explanations are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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