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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Nov;64(3):878–883. doi: 10.1073/pnas.64.3.878

INHIBITION OF HERPES SIMPLEX VIRUS BY SYNTHETIC DOUBLE-STRANDED RNA (POLYRIBOADENYLIC AND POLYRIBOURIDYLIC ACIDS AND POLYRIBOINOSINIC AND POLYRIBOCYTIDYLIC ACIDS)*

L D Hamilton 1,2, Virginia I Babcock 1,2, C M Southam 1,2
PMCID: PMC223316  PMID: 4313333

Abstract

Two-stranded polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids protect against herpes simplex virus-induced cytopathogenicity in HEp 2 cultures, systemic herpes simplex virus infection in mice, and herpes simplex virus-induced keratoconjunctivitis in rabbits.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FERRARI W., GESSA G. L., LODDO B., SCHIVO M. L. DECREASED PATHOGENICITY FOR RABBIT SKIN OF IDU-RESISTANT VACCINIA VIRUS. Virology. 1965 May;26:154–155. doi: 10.1016/0042-6822(65)90039-5. [DOI] [PubMed] [Google Scholar]
  2. Field A. K., Lampson G. P., Tytell A. A., Nemes M. M., Hilleman M. R. Inducers of interferon and host resistance, IV. Double-stranded replicative form RNA (MS2-Ff-RNA) from E. coli infected with MS2 coliphage. Proc Natl Acad Sci U S A. 1967 Nov;58(5):2102–2108. doi: 10.1073/pnas.58.5.2102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004–1010. doi: 10.1073/pnas.58.3.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hamilton L. D. DNA: models and reality. Nature. 1968 May 18;218(5142):633–637. doi: 10.1038/218633a0. [DOI] [PubMed] [Google Scholar]
  5. KAUFMAN H. E., NESBURN A. B., MALONEY E. D. IDU therapy of herpes simplex. Arch Ophthalmol. 1962 May;67:583–591. doi: 10.1001/archopht.1962.00960020583012. [DOI] [PubMed] [Google Scholar]
  6. Lampson G. P., Tytell A. A., Field A. K., Nemes M. M., Hilleman M. R. Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. Proc Natl Acad Sci U S A. 1967 Aug;58(2):782–789. doi: 10.1073/pnas.58.2.782. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MOORE A. E., SABACHEWSKY L., TOOLAN H. W. Culture characteristics of four permanent lines of human cancer cells. Cancer Res. 1955 Oct;15(9):598–602. [PubMed] [Google Scholar]
  8. Park J. H., Baron S. Herpetic keratoconjunctivitis: therapy with synthetic double-stranded RNA. Science. 1968 Nov 15;162(3855):811–813. doi: 10.1126/science.162.3855.811. [DOI] [PubMed] [Google Scholar]
  9. Richmond J. Y., Hamilton L. D. Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A. 1969 Sep;64(1):81–86. doi: 10.1073/pnas.64.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Tytell A. A., Lampson G. P., Field A. K., Hilleman M. R. Inducers of interferon and host resistance. 3. Double-stranded RNA from reovirus type 3 virions (reo 3-RNA). Proc Natl Acad Sci U S A. 1967 Oct;58(4):1719–1722. doi: 10.1073/pnas.58.4.1719. [DOI] [PMC free article] [PubMed] [Google Scholar]

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