Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Nov;64(3):952–956. doi: 10.1073/pnas.64.3.952

MAREK'S DISEASE HERPES VIRUS: A CYTOMEGALOVIRUS?*

Lucy F Lee 1,2, Bernard Roizman 1,2, Patricia G Spear 1,2,†, Elliott D Kieff 1,2,‡, B R Burmester 1,2, K Nazerian 1,2
PMCID: PMC223327  PMID: 4313336

Abstract

The DNA of herpes viruses associated with Marek's disease of fowl contains 56-57 moles of guanine and cytosine per 100. The composition of its DNA and lack of infectiousness of cell-free preparations suggest that the herpes virus associated with Marek's disease belongs to the herpes virus group B which contains predominantly cytomegaloviruses.

Full text

PDF
952

Images in this article

954Image
on p.954
954Image
on p.954
954Image
on p.954
954Image
on p.954

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURKITT D. A sarcoma involving the jaws in African children. Br J Surg. 1958 Nov;46(197):218–223. doi: 10.1002/bjs.18004619704. [DOI] [PubMed] [Google Scholar]
  2. Churchill A. E., Biggs P. M. Agent of Marek's disease in tissue culture. Nature. 1967 Jul 29;215(5100):528–530. doi: 10.1038/215528a0. [DOI] [PubMed] [Google Scholar]
  3. Churchill A. E., Biggs P. M. Herpes-type virus isolated in cell culture from tumors of chickens with Marek's disease. II. Studies in vivo. J Natl Cancer Inst. 1968 Oct;41(4):951–956. [PubMed] [Google Scholar]
  4. Churchill A. E. Herpes-type virus isolated in cell culture from tumors of chickens with Marek's disease. I. Studies in cell culture. J Natl Cancer Inst. 1968 Oct;41(4):939–950. [PubMed] [Google Scholar]
  5. Churchill A. E., Payne L. N., Chubb R. C. Immunization against Marek's disease using a live attenuated virus. Nature. 1969 Feb 22;221(5182):744–747. doi: 10.1038/221744a0. [DOI] [PubMed] [Google Scholar]
  6. EAGLE H. Amino acid metabolism in mammalian cell cultures. Science. 1959 Aug 21;130(3373):432–437. doi: 10.1126/science.130.3373.432. [DOI] [PubMed] [Google Scholar]
  7. EPSTEIN M. A., ACHONG B. G., BARR Y. M. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA. Lancet. 1964 Mar 28;1(7335):702–703. doi: 10.1016/s0140-6736(64)91524-7. [DOI] [PubMed] [Google Scholar]
  8. Epstein M. A., Achong B. G., Churchill A. E., Biggs P. M. Structure and development of the herpes-types virus of Marek's disease. J Natl Cancer Inst. 1968 Sep;41(3):805–820. [PubMed] [Google Scholar]
  9. FAWCETT D. W. Electron microscope observations on intracellular virus-like particles associated with the cells of the Lucké renal adenocarcinoma. J Biophys Biochem Cytol. 1956 Nov 25;2(6):725–741. doi: 10.1083/jcb.2.6.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hsiung G. D., Kaplow L. S. Herpeslike virus isolated from spontaneously degenerated tissue culture derived from leukemia-susceptible guinea pigs. J Virol. 1969 Mar;3(3):355–357. doi: 10.1128/jvi.3.3.355-357.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MELNICK J. L., MIDULLA M., WIMBERLY I., BARRERA-ORO J. G., LEVY B. M. A NEW MEMBER OF THE HERPESVIRUS GROUP ISOLATED FROM SOUTH AMERICAN MARMOSETS. J Immunol. 1964 Apr;92:596–601. [PubMed] [Google Scholar]
  12. Meléndez L. V., Hunt R. D., Daniel M. D., García F. G., Fraser C. E. Herpesvirus saimiri. II. Experimentally induced malignant lymphoma in primates. Lab Anim Care. 1969 Jun;19(3):378–386. [PubMed] [Google Scholar]
  13. Nazerian K., Burmester B. R. Electron microscopy of a herpes virus associated with the agent of Marek's disease in cell culture. Cancer Res. 1968 Dec;28(12):2454–2462. [PubMed] [Google Scholar]
  14. Nazerian K., Solomon J. J., Witter R. L., Burmester B. R. Studies on the etiology of Marek's disease. II. Finding of a herpesvirus in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):177–182. doi: 10.3181/00379727-127-32650. [DOI] [PubMed] [Google Scholar]
  15. ROIZMAN B., AURELIAN L. ABORTIVE INFECTION OF CANINE CELLS BY HERPES SIMPLEX VIRUS. I. CHARACTERIZATION OF VIRAL PROGENY FROM CO-OPERATIVE INFECTION WITH MUTANTS DIFFERING IN CAPACITY TO MULTIPLY IN CANINE CELLS. J Mol Biol. 1965 Mar;11:528–538. doi: 10.1016/s0022-2836(65)80008-0. [DOI] [PubMed] [Google Scholar]
  16. Roizman B., Spear P. G. Preparation of herpes simplex virus of high titer. J Virol. 1968 Jan;2(1):83–84. doi: 10.1128/jvi.2.1.83-84.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Solomon J. J., Witter R. L., Nazerian K., Burmester B. R. Studies on the etiology of Marek's disease. I. Propagation of the agent in cell culture. Proc Soc Exp Biol Med. 1968 Jan;127(1):173–177. doi: 10.3181/00379727-127-32649. [DOI] [PubMed] [Google Scholar]
  18. Wagner E. K., Roizman B. Ribonucleic acid synthesis in cells infected with herpes simplex virus. I. Patterns of ribonucleic acid synthesis in productively infected cells. J Virol. 1969 Jul;4(1):36–46. doi: 10.1128/jvi.4.1.36-46.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Wight P. A., Wilson J. E., Campbell J. G., Fraser E. Virus-like particles in blood lymphocytes in acute Marek's disease. Nature. 1967 Nov 25;216(5117):804–805. doi: 10.1038/216804a0. [DOI] [PubMed] [Google Scholar]
  20. Witter R. L., Burgoyne G. H., Solomon J. J. Evidence for a herpesvirus as an etiologic agent of marek's disease. Avian Dis. 1969 Feb;13(1):171–184. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES