Abstract
Manual review of antibiotic sensitivity testing results is an essential component of a microbiology laboratory's quality control process. Such review is tedious and prone to human error, however. An expert system is described that remembers which susceptibility patterns are considered typical or atypical by expert reviewers, then uses these to prescreen future isolates. It uses a similarity function to allow matching against this library when two patterns are close, but not identical. Use of this system allows more efficient and reliable review of the laboratory's antibiotic sensitivity testing results.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Edwards M., Cooley R. E. Expertise in expert systems: knowledge acquisition for biological expert systems. Comput Appl Biosci. 1993 Dec;9(6):657–665. doi: 10.1093/bioinformatics/9.6.657. [DOI] [PubMed] [Google Scholar]
- Giacca M., Menzo S., Trojan S., Monti-Bragadin C. Cluster analysis of antibiotic susceptibility patterns of clinical isolates as a tool in nosocomial infection surveillance. Eur J Epidemiol. 1987 Jun;3(2):155–163. doi: 10.1007/BF00239753. [DOI] [PubMed] [Google Scholar]
- Giuse D. A., Giuse N. B., Miller R. A. Evaluation of long-term maintenance of a large medical knowledge base. J Am Med Inform Assoc. 1995 Sep-Oct;2(5):297–306. doi: 10.1136/jamia.1995.96073832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hindler J. Non-traditional approaches for quality control of antimicrobial susceptibility tests. Adv Exp Med Biol. 1994;349:67–85. doi: 10.1007/978-1-4757-9206-5_7. [DOI] [PubMed] [Google Scholar]
- Kahn M. G., Steib S. A., Fraser V. J., Dunagan W. C. An expert system for culture-based infection control surveillance. Proc Annu Symp Comput Appl Med Care. 1993:171–175. [PMC free article] [PubMed] [Google Scholar]
- Nusbaum N. J. Computers and the clinical laboratory. Med Hypotheses. 1995 Jan;44(1):70–72. doi: 10.1016/0306-9877(95)90306-2. [DOI] [PubMed] [Google Scholar]
- Sahm D. F., O'Brien T. F. Detection and surveillance of antimicrobial resistance. Trends Microbiol. 1994 Oct;2(10):366–371. doi: 10.1016/0966-842x(94)90613-0. [DOI] [PubMed] [Google Scholar]
- Spackman K. A. Quality assurance, knowledge-based systems, and machine learning. Med Decis Making. 1991 Jul-Sep;11(3):153–153. doi: 10.1177/0272989X9101100301. [DOI] [PubMed] [Google Scholar]
- Sumner W., 2nd, Shultz E. K. Expert systems and expert behavior. J Med Syst. 1992 Oct;16(5):183–193. doi: 10.1007/BF01000271. [DOI] [PubMed] [Google Scholar]
