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. 1969 Nov;64(3):1095–1102. doi: 10.1073/pnas.64.3.1095

GENETIC CONTROL OF IMMUNOLOGICAL RESPONSIVENESS IN GUINEA PIGS TO 2,4-DINITROPHENYL CONJUGATES OF POLY-L-ARGININE, PROTAMINE, AND POLY-L-ORNITHINE

Ira Green 1, William E Paul 1, Baruj Benacerraf 1
PMCID: PMC223348  PMID: 4984383

Abstract

The ability of guinea pigs to respond immunologically to dinitrophenyl (DNP)-poly-L-arginine, DNP-protamine, DNP polyornithine, and to unsubstituted poly-L-arginine and protamine is linked to the presence of the poly-L-lysine gene. This gene has previously been demonstrated to control the immune response of guinea pigs to poly-L-lysine, to a copolymer of L-glutamic acid and L-lysine and to haptenic derivatives of these materials.

Although the ability to respond to each of these highly charged compounds is linked to the presence of the poly-L-lysine gene, the cellular immune responses to these antigens is highly individually specific.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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