Abstract
It is suggested that the development of a dominant character in higher organisms starts with the activation of a major gene. This gene replicates; the number of replicas is controlled by a second gene or set of genes, which also ensure that the most suitable allele, if more than one is present, makes the replicas. The major gene replicas then make messenger RNA and are reinforced in this by minor genes. The joint product of major gene replicas and minor genes activates a fourth gene or set of genes which produce a repressor that damps down the activity of the major gene replicas. The evidence for this scheme, which comes from studies of selection experiments in populations, is summarized and the evidence from studies of DNA and RNA metabolism is referred to in this paper.
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Selected References
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- Brown D. D., Dawid I. B. Specific gene amplification in oocytes. Oocyte nuclei contain extrachromosomal replicas of the genes for ribosomal RNA. Science. 1968 Apr 19;160(3825):272–280. doi: 10.1126/science.160.3825.272. [DOI] [PubMed] [Google Scholar]
- Gall J. G. Differential synthesis of the genes for ribosomal RNA during amphibian oögenesis. Proc Natl Acad Sci U S A. 1968 Jun;60(2):553–560. doi: 10.1073/pnas.60.2.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kiefer B. I. Dosage regulation of ribosomal DNA in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1968 Sep;61(1):85–89. doi: 10.1073/pnas.61.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kindred B. Selection for canalisation in mice. Genetics. 1967 Apr;55(4):635–644. doi: 10.1093/genetics/55.4.635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rendel J. M., Sheldon B. L., Finlay D. E. Canalisation of development of scutellar bristles in Drosophila by control of the scute locus. Genetics. 1965 Dec;52(6):1137–1151. doi: 10.1093/genetics/52.6.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ritossa F. M. Unstable redundancy of genes for ribosomal RNA. Proc Natl Acad Sci U S A. 1968 Jun;60(2):509–516. doi: 10.1073/pnas.60.2.509. [DOI] [PMC free article] [PubMed] [Google Scholar]