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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Jul;63(3):740–747. doi: 10.1073/pnas.63.3.740

TRANSFORMATION AND CHROMOSOME CHANGES INDUCED BY EPSTEIN-BARR VIRUS IN NORMAL HUMAN LEUKOCYTE CULTURES

Paul Gerber 1,2,3, Jacqueline Whang-Peng 1,2,3, James H Monroe 1,2,3
PMCID: PMC223514  PMID: 5259761

Abstract

Three separate attempts to establish long-term leukocyte cultures from the peripheral blood of a healthy adult who had no evidence of previous infection with Epstein-Barr virus were consistently unsuccessful. On the other hand, in vitro infection of buffy-coat cells of this donor with Epstein-Barr virus resulted in blastoid transformation of the lymphocytes and long-term growth potential. The transformation was accompanied by major chromosome changes. The significance of these findings in relation to lymphoproliferative diseases in man remains to be determined.

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Selected References

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