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. 1969 Jul;63(3):850–855. doi: 10.1073/pnas.63.3.850

A LIPID REQUIREMENT FOR INDUCTION OF LACTOSE TRANSPORT IN Escherichia coli*

C Fred Fox 1,†
PMCID: PMC223530  PMID: 4899880

Abstract

The rate of derepressed synthesis of a membrane protein required for lactose transport (M protein) by Escherichia coli is increased in response to increased gene dosage to the same extent as the rates of synthesis of β-galactosidase and galactoside acetylase. However, elevated gene dosage does not increase β-galactoside transport to the same extent that it increases synthesis of M protein and of the soluble proteins of the lac operon. Though the factor or factors other than M protein which limit induction of the transport system at high levels of lac operon expression have not been identified, studies with Escherichia coli mutants blocked in the synthesis of unsaturated fatty acids indicate that unsaturated fatty acids must be supplied during the course of induction of the lac operon to permit synthesis of a functional lactose transport system, but not of β-galactosidase or galactoside acetylase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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