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. 1987 Jun;98(3):379–383. doi: 10.1017/s0950268800062142

Does chloramphenicol remain the drug of choice for typhoid?

B Rowe, E J Threlfall, L R Ward
PMCID: PMC2235375  PMID: 3595753

Abstract

Of 2356 strains of Salmonella typhi isolated in Britain in the 8-year period 1978-85, 2345 (99.53%) were sensitive to all antibiotics tested and 11 (0.47%) were chloramphenicol-resistant; chloramphenicol resistance was plasmid-mediated in 6 strains. It is concluded that chloramphenicol remains a satisfactory first-line choice of drug for typhoid fever in Britain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. S., Smith H. R. Chloramphenicol resistance in the typhoid bacillus. Br Med J. 1972 Aug 5;3(5822):329–331. doi: 10.1136/bmj.3.5822.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson E. S. The problem and implications of chloramphenicol resistance in the typhoid bacillus. J Hyg (Lond) 1975 Apr;74(2):289–299. doi: 10.1017/s0022172400024360. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Birnboim H. C., Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res. 1979 Nov 24;7(6):1513–1523. doi: 10.1093/nar/7.6.1513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Butler T., Linh N. N., Arnold K., Pollack M. Chloramphenicol-resistant typhoid fever in Vietnam associated with R factor. Lancet. 1973 Nov 3;302(7836):983–985. doi: 10.1016/s0140-6736(73)91086-6. [DOI] [PubMed] [Google Scholar]
  5. Farrar W. E. Antibiotic resistance in developing countries. J Infect Dis. 1985 Dec;152(6):1103–1106. doi: 10.1093/infdis/152.6.1103. [DOI] [PubMed] [Google Scholar]
  6. Kado C. I., Liu S. T. Rapid procedure for detection and isolation of large and small plasmids. J Bacteriol. 1981 Mar;145(3):1365–1373. doi: 10.1128/jb.145.3.1365-1373.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Paniker C. K., Vimala K. N. Transferable chloramphenicol resistance in Salmonella typhi. Nature. 1972 Sep 8;239(5367):109–110. doi: 10.1038/239109b0. [DOI] [PubMed] [Google Scholar]
  8. Sharma K. B., Bhat M. B., Pasricha A., Vaze S. Multiple antibiotic resistance among salmonellae in India. J Antimicrob Chemother. 1979 Jan;5(1):15–21. doi: 10.1093/jac/5.1.15. [DOI] [PubMed] [Google Scholar]
  9. Taylor D. E., Chumpitaz J. C., Goldstein F. Variability of IncHI1 plasmids from Salmonella typhi with special reference to Peruvian plasmids encoding resistance to trimethoprim and other antibiotics. Antimicrob Agents Chemother. 1985 Sep;28(3):452–455. doi: 10.1128/aac.28.3.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Threlfall E. J., Rowe B., Ferguson J. L., Ward L. R. Characterization of plasmids conferring resistance to gentamicin and apramycin in strains of Salmonella typhimurium phage type 204c isolated in Britain. J Hyg (Lond) 1986 Dec;97(3):419–426. doi: 10.1017/s0022172400063609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ti T. Y., Monteiro E. H., Lam S., Lee H. S. Ceftriaxone therapy in bacteremic typhoid fever. Antimicrob Agents Chemother. 1985 Oct;28(4):540–543. doi: 10.1128/aac.28.4.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Uwaydah M., Nassar N. T., Harakeh H., Vartivarian S., Talhouk A., Kantarjian H. Treatment of typhoid fever with cefamandole. Antimicrob Agents Chemother. 1984 Sep;26(3):426–427. doi: 10.1128/aac.26.3.426. [DOI] [PMC free article] [PubMed] [Google Scholar]

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