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. 1969 Jul;63(3):918–925. doi: 10.1073/pnas.63.3.918

STIMULATION OF ANTERIOR PITUITARY ADENYL CYCLASE ACTIVITY AND ADENOSINE 3′:5′-CYCLIC PHOSPHATE BY HYPOTHALAMIC EXTRACT AND PROSTAGLANDIN E1*

Uriel Zor 1,2,3, Toshio Kaneko 1,2,3, Herman P G Schneider 1,2,3, Samuel M McCann 1,2,3, Irene P Lowe 1,2,3, Gail Bloom 1,2,3, Barbara Borland 1,2,3, James B Field 1,2,3
PMCID: PMC223540  PMID: 4310517

Abstract

Hypothalamic extract, containing the releasing factors for anterior pituitary hormones, within minutes stimulated adenyl cyclase activity and adenosine 3′:5′-cyclic phosphate (cyAMP) concentrations in rat anterior pituitary in vitro. Cerebral cortical extract was ineffective and hypothalamic extract had no effect on these parameters in posterior pituitary or thyroid. Prostaglandin E1 also increased adenyl cyclase activity and cyAMP levels in anterior pituitary tissue. Although NaF augmented adenyl cyclase activity, it did not elevate cyAMP. Epinephrine, norepinephrine, histamine, serotonin, dopamine, and vasopressin did not increase either adenyl cyclase or cyAMP. The increased adenyl cyclase and cyAMP produced by hypothalamic extract was associated with greater luteinizing hormone release from anterior pituitary in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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