Abstract
The predominant basis for transport interactions between neutral and cationic amino acids in the Ehrlich ascites-tumor cell and the rabbit reticulocyte has been identified as a reaction of the neutral amino acid plus Na+ with the cationic amino acid transport system. This reaction is revealed both by a Na+-dependent transport inhibition by the neutral amino acid, and by mutual flux accelerations whereby the neutral amino acid and Na+ exchange for the cationic amino acid.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHRISTENSEN H. N. A TRANSPORT SYSTEM SERVING FOR MONO- AND DIAMINO ACIDS. Proc Natl Acad Sci U S A. 1964 Feb;51:337–344. doi: 10.1073/pnas.51.2.337. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHRISTENSEN H. N., RIGGS T. R. Concentrative uptake of amino acids by the Ehrlich mouse ascites carcinoma cell. J Biol Chem. 1952 Jan;194(1):57–68. [PubMed] [Google Scholar]
- Christensen H. N., Antonioli J. A. Cationic amino acid transport in the rabbit reticulocyte. Na+-dependent inhibition of Na+-independent transport. J Biol Chem. 1969 Mar 25;244(6):1497–1504. [PubMed] [Google Scholar]
- Christensen H. N., Handlogten M. E., Lam I., Tager H. S., Zand R. A bicyclic amino acid to improve discriminations among transport systems. J Biol Chem. 1969 Mar 25;244(6):1510–1520. [PubMed] [Google Scholar]
- Christensen H. N., Handlogten M. E. Modes of mediated exodus of amino acids from the Ehrlich ascites tumor cell. J Biol Chem. 1968 Oct 25;243(20):5428–5438. [PubMed] [Google Scholar]
- Christensen H. N., Liang M., Archer E. G. A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids. J Biol Chem. 1967 Nov 25;242(22):5237–5246. [PubMed] [Google Scholar]
- Christensen H. N., Liang M. Transport of diamino acids into the Ehrlich cell. J Biol Chem. 1966 Dec 10;241(23):5542–5551. [PubMed] [Google Scholar]
- Christensen H. N. Some special kinetic problems of transport. Adv Enzymol Relat Areas Mol Biol. 1969;32:1–20. doi: 10.1002/9780470122778.ch1. [DOI] [PubMed] [Google Scholar]
- Eddy A. A. The effects of varying the cellular and extracellular concentrations of sodium and potassium ions on the uptake of glycine by mouse ascites-tumour cells in the presence and absence of sodium cyanide. Biochem J. 1968 Jul;108(3):489–498. doi: 10.1042/bj1080489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gillespie E. Homo- and hetero-exchange diffusion of amino acids in Ehrlich ascites carcinoma cells. Biochim Biophys Acta. 1967;135(5):1016–1029. doi: 10.1016/0005-2736(67)90072-7. [DOI] [PubMed] [Google Scholar]
- KAMIN H., HANDLER P. Effect of infusion of single amino acids upon excretion of other amino acids. Am J Physiol. 1951 Mar;164(3):654–661. doi: 10.1152/ajplegacy.1951.164.3.654. [DOI] [PubMed] [Google Scholar]
- Margolis R. K., Lajtha A. Ion dependence of amino acid uptake in brain slices. Biochim Biophys Acta. 1968 Nov 5;163(3):374–385. doi: 10.1016/0005-2736(68)90122-3. [DOI] [PubMed] [Google Scholar]
- Munck B. G. Amino acid transport by the small intestine of the rat. On the counterflow phenomenon as a cause of the accelerating effect of leucine on the transintestinal transport of diamino acids. Biochim Biophys Acta. 1966 Jun 8;120(2):282–291. doi: 10.1016/0926-6585(66)90348-7. [DOI] [PubMed] [Google Scholar]
- OXENDER D. L., CHRISTENSEN H. N. DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL. J Biol Chem. 1963 Nov;238:3686–3699. [PubMed] [Google Scholar]
- RIGGS T. R., WALKER L. M., CHRISTENSEN H. N. Potassium migration and amino acid transport. J Biol Chem. 1958 Dec;233(6):1479–1484. [PubMed] [Google Scholar]
- VIDAVER G. A. MUCATE INHIBITION OF GLYCINE ENTRY INTO PIGEON RED CELLS. Biochemistry. 1964 Jun;3:799–803. doi: 10.1021/bi00894a012. [DOI] [PubMed] [Google Scholar]
- Wheeler K. P., Christensen H. N. Interdependent fluxes of amino acids and sodium ion in the pigeon red blood cell. J Biol Chem. 1967 Sep 10;242(17):3782–3788. [PubMed] [Google Scholar]